N/A
N=16
Investigation of the Effects of Dietary Fibres on the Gut Microbiome in a Transgenerational Cohort
Gut Health
Bottom Line
View on ClinicalTrials.gov: NCT05364437 ↗Enrolled (actual)
16
Serious AEs
0.0%
Results posted
Apr 2025
Primary outcome: Primary: Stool Short-chain Fatty Acids Production Following Each Intervention Between Mothers and Daughters — 50; 26; 41.7; 47.8 umol/g
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Dietary Fibres Supplement (Dietary_supplement); Cellulose Control (Dietary_supplement)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- Female
- Sponsor
- Imperial College London
- Primary completion
- Apr 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Stool Short-chain Fatty Acids Production Following Each Intervention Between Mothers and Daughters |
50; 26; 41.7; 47.8 | — |
| SECONDARY Gut Microbiota Composition Changes Following Each Supplement Intake Between Mothers and Daughters |
— | — |
| SECONDARY Urine Metabolites Comparison Between Mothers and Daughters After Taking Each Supplement |
— | — |
| SECONDARY Stool Metabolites Comparison Between Mothers and Daughters After Taking Each Supplement |
— | — |
| SECONDARY Blood Glucose in Mothers Compared to Daughters After Taking Each Supplement for 14 Days |
— | — |
| SECONDARY Blood Glucose for Mothers and Daughters After Taking Each Supplement for 14 Days |
— | — |
| SECONDARY Blood Insulin Comparison Between Mothers and Daughters After Each Generation Took the Dietary Supplements |
— | — |
| SECONDARY Blood Insulin Comparison Between Mothers and Daughters After Taking Each Supplement for 14 Days |
— | — |
| SECONDARY Gut Hormones in Mothers Versus Daughters |
— | — |
| SECONDARY Gut Hormones in Mothers Who Took Each Dietary Supplement Versus Gut Hormones in Daughters Who Took Each Dietary Supplement |
— | — |
Summary
Dietary fibres are complex carbohydrates present in fruit, vegetables, grains, and beans which are broken down into smaller molecules (short-chain fatty acids) in the colon by the gut microbiota. Increased intake of dietary fibres is associated with a lower risk of type 2 diabetes, obesity, or heart disease. Despite their health benefits, most people consume half of the daily recommended intake (30 grams) of dietary fibres. This trend has become more apparent in the past few decades with the advent of ultra-processed foods which are poor in dietary fibres. Since this change in dietary habits is more recent, the research team hypothesizes that older generations have a more diverse and better adapted gut microbiota at breaking down dietary fibres compared to younger generations.
The aims of this study are to examine the effects of the daily intake over four weeks of a dietary fibres supplement on the gut microbiota, metabolic profiles, and general health in a transgenerational cohort (grandmother, mother and daughter OR mother and daughter) compared to cellulose control.
Eligibility Criteria
Inclusion Criteria
- Any of the following groups of people (in direct descent and from the same family) Grandmother, mother and daughter Mother and daughter Grandmother and granddaughter
- Age 18-85 (inclusive)
- BMI: 18.5-30 kg/m2 (inclusive)
- Considering themselves healthy
Exclusion Criteria
- Intake of antibiotics in the past 3 months and during the study
- Intake of probiotic supplements in the past month and during the study
- Regular intake of laxatives in the past month and during the study
- Subjects with the following conditions Inflammatory Bowel Disease (IBD) Irritable Bowel Syndrome (IBS) Coeliac Disease Type 2 Diabetes Any type of cancer Autoimmune conditions Conditions that affect the liver Conditions that affect the pancreas
- Subjects who require medical intervention in the coming 3 months
- Smokers
- Shift workers
- Gluten and/or lactose intolerance
- Pregnant and lactating women
- Subjects living in care homes
- had weight changes >5% in the preceding 3 months
- Subjects who are unable to give informed consent by themselves
- Subjects who are currently participating in other clinical trials
Data sourced from ClinicalTrials.gov (NCT05364437). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.