N/A
N=99
Fear, Gastrointestinal Distress, and Interoception: Physiological and Psychological Mechanisms in Eating Disorders
Feeding and Eating Disorders
Bottom Line
View on ClinicalTrials.gov: NCT05382702 ↗Enrolled (actual)
99
Serious AEs
0.0%
Results posted
Apr 2026
Primary outcome: Primary: Subjective Rating of Fear — -36.9444; -23.9219; -47.3611; 85.6250 units on scale*minutes — p=.879
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Test meal description changed (Other)
- Age
- Adult · 18+ yrs
- Sex
- Female
- Sponsor
- Ohio University
- Primary completion
- Mar 2025
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Subjective Rating of Fear |
-36.9444; -23.9219; -47.3611; 85.6250 | .879 |
| PRIMARY Difference in Average Skin Conductance |
.5076; .4773; 1.0938; .6715 | .059 |
| PRIMARY Gastrointestinal Distress |
19.5694; -2.0469; -59.5417; 31.5078 | .468 |
| PRIMARY Cholecystokinin Response |
.5147; 20.9534; .3726; 5.2803 | .616 |
| PRIMARY Peptide YY Response |
-.0336; 7.6352; 25.0249; 3.6242 | .498 |
| PRIMARY Subjective Rating of Fullness |
1311.9697; 2123.7097; 1612.9545; 1769.8387 | .946 |
| PRIMARY Urges to Restrict Food Intake |
34.6486; 42.0938; 32.3243; 45.125 | .950 |
Summary
The proposed study tests fear, gut peptide response, and perceptions of fullness as causes of gastrointestinal distress and eating disorder maintenance.
Eligibility Criteria
Inclusion Criteria
- female
- DSM-5 eating disorder
- score 16 or higher on the Clinical Impairment Assessment
- experience nausea or stomachache after eating at least "sometimes"
- 18 to 40 years old
- body mass index between 18.5 and 26.5 kg/m2
Exclusion Criteria
- medical conditions affect appetite or weight
- Recent pregnancy or current breastfeeding
- Dairy, strawberry or honey food allergy
- Specific phobia, blood-injection-injury type
Data sourced from ClinicalTrials.gov (NCT05382702). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.