N/A
Completed N=57,837
INSPIRE Trial for Skin and Soft Tissue Infections
Skin and Soft Tissue (SST) Infection
Source: ClinicalTrials.gov NCT05423756 ↗
Enrolled (actual)
57,837
Serious AEs
0.0%
Results posted
Aug 2025
Primary outcomePrimary: Extended-Spectrum Days of Antibacterial Therapy (ES-DOT) Per Empiric Day — 43305; 40156; 43927; 30287 Extended-Spectrum Days-of-Therapy
Summary
The INSPIRE Skin and Soft Tissue Infection trial is a cluster-randomized controlled trial of HCA Healthcare hospitals comparing routine empiric antibiotic stewardship practices with real-time, precision medicine computerized physician order entry (CPOE) smart prompts providing the probability that a non-critically ill adult admitted with skin and soft tissue infection is infected with a resistant pathogen.
Note: enrolled "subjects" represent 102 individual HCA Healthcare hospitals that have been randomized into 92 clusters. Hospitals were grouped into the same randomization cluster if they shared campuses or antibiotic stewardship staff.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Extended-Spectrum Days of Antibacterial Therapy (ES-DOT) Per Empiric Day |
43305; 40156; 43927; 30287 | — |
| SECONDARY Antipseudomonal Antibiotic Days Of Therapy (ES-DOT) Per Empiric Day |
43305; 38059; 43927; 30287 | — |
Eligibility Criteria
Facility Inclusion Criteria:
- HCA Healthcare hospitals admitting adults for skin and soft tissue infection
- Facility use of MEDITECH as their electronic health record system
Facility Exclusion Criteria:
-
Note: unit of randomization is the hospital, however the computerized physician order entry (CPOE) alert intervention will calculate risk estimates for adults age >=18 admitted to non-intensive care unit wards and who are ordered to receive extended-spectrum antibiotics for skin and soft tissue infection.
Data sourced from ClinicalTrials.gov (NCT05423756). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.