N/A
N=21
Using Real-time fMRI Neurofeedback and Motor Imagery to Enhance Motor Timing and Precision in Cerebellar Ataxia
Cerebellar Ataxia · Spinocerebellar Ataxias · Cerebellar Degeneration
Bottom Line
View on ClinicalTrials.gov: NCT05436262 ↗Enrolled (actual)
21
Serious AEs
0.0%
Results posted
Jan 2025
Primary outcome: Primary: Change in Overt Tapping Accuracy as Assessed by Finger Tapping to a Flashing Cue at 1Hz Speed — .00141488 taps per second
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Real-time fMRI with neurofeedback of motor imagery (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Johns Hopkins University
- Primary completion
- Jan 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Overt Tapping Accuracy as Assessed by Finger Tapping to a Flashing Cue at 1Hz Speed |
.00141488 | — |
| PRIMARY Change in Overt Tapping Accuracy as Assessed by Finger Tapping to a Flashing Cue at 4Hz Speed |
.00165387 | — |
| PRIMARY Change in At-home Overt Tapping Accuracy as Assessed by Finger Tapping to a Flashing Cue at 1Hz Speed |
.392919831; .200339199 | — |
| PRIMARY Change in At-home Overt Tapping Accuracy as Assessed by Finger Tapping to a Flashing Cue at 4Hz Speed |
.35613192; .067492801 | — |
| SECONDARY The Correlation Between MRI BOLD During Imagery and Finger Tapping Accuracy Improvements to a Flashing Cue at 1Hz as Assessed by a Correlation Coefficient |
.850; .861; .838; .842; .884; .850 | — |
| SECONDARY The Correlation Between MRI BOLD and Finger Tapping Accuracy to a Flashing Cue at 4Hz as Assessed by a Correlation Coefficient |
.688 | — |
| SECONDARY The Correlation Between the KVIQ and Imagery Accuracy of the Flashing Cross on the MRI Task as Assessed by a Correlation Coefficient |
.953 | — |
| SECONDARY The Correlation Between the ICARS and Imagery Accuracy Accuracy of the Flashing Cross on the MRI Task as Assessed by a Correlation Coefficient |
-.263 | — |
Summary
The aim of the research is to improve motor function in people with cerebellar ataxia by using neuroimaging methods and mental imagery to "exercise" motor networks in the brain. The relevance of this research to public health is that results have the potential to reduce motor deficits associated with cerebellar atrophy, thereby enhancing the quality of life and promoting independence.
Eligibility Criteria
Inclusion Criteria
- 18-100 years of age
- At least 8th-grade education
- Right-handedness
- Clinical diagnosis of progressive, degenerative cerebellar ataxia by a movement disorder specialist (cerebellar ataxia of unknown etiology, and spinocerebellar ataxias with and without genetic confirmation)
Exclusion Criteria
- History of Axis I psychiatric disorders (including alcohol and drug dependence)
- Severe or unstable medical disorder, neurological disorders, such as stroke or epilepsy
- History of head injury that resulted in a loss of consciousness greater than 5 minutes and/or neurological sequelae
- Any condition that is contraindicated for the MRI environment (e.g., metal in the body, pacemaker, claustrophobia)
- Currently pregnant
- Clinical diagnosis of multiple system atrophy (MSA) or Friedrich's ataxia (FA)
- Eligible subjects may be asked to refrain from medications that affect the central nervous system that would also make data difficult to interpret (e.g., sedatives) for an appropriate period of time prior to scanning
- Participants will be excluded if the participants do not have a home computer with internet available to complete the 3-week at-home component of the study protocol
Data sourced from ClinicalTrials.gov (NCT05436262). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.