Phase 1
Completed N=36
A Study of Effects of Selpercatinib in Hepatically Impaired Participants and Healthy Participants
Healthy · Hepatic Impairment
Source: ClinicalTrials.gov NCT05436912 ↗
Enrolled (actual)
36
Serious AEs
0.0%
Results posted
Apr 2025
Primary outcomePrimary: Pharmacokinetics (PK): Maximum Concentration (Cmax) of Selpercatinib — 898; 1170; 732; 952 nanogram per milliliter (ng/mL) — p=0.3601
Summary
The main purpose of this study is to assess how selpercatinib gets into the blood stream and how long it takes the body to remove it when administered to participants with impaired hepatic function compared to healthy participants. Information about safety and tolerability will be collected. The study will last up to about 7 weeks, inclusive of screening period.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pharmacokinetics (PK): Maximum Concentration (Cmax) of Selpercatinib |
898; 1170; 732; 952 | 0.3601 |
| PRIMARY PK: Time to Reach Cmax (Tmax) of Selpercatinib |
2.00; 1.53; 2.00; 1.50 | — |
| PRIMARY PK: Area Under the Concentration-time Curve (AUC), From Time 0 to the Last Observed Non-zero Concentration (AUC0-t) of Selpercatinib |
17700; 20200; 14600; 27100 | 0.4279 |
| PRIMARY PK: AUC Extrapolated to Infinity (AUC0-∞) of Selpercatinib |
17700; 20200; 14700; 27300 | 0.4289 |
| PRIMARY PK: Percentage Extrapolation for AUC (%AUCextrap) of Selpercatinib |
0.422; 0.310; 0.373; 0.685 | — |
| PRIMARY PK: Apparent Terminal Elimination Rate Constant (λz) of Selpercatinib |
0.0220; 0.0266; 0.0320; 0.0175 | — |
| PRIMARY PK: Apparent Terminal Elimination Half-life (t1/2) of Selpercatinib |
36.4; 27.9; 22.4; 41.3 | — |
| PRIMARY PK: Apparent Systemic Clearance (CL/F) of Selpercatinib |
9.03; 7.90; 10.9; 5.87 | — |
| PRIMARY PK: Apparent Volume of Distribution During the Terminal Phase (Vd/F) of Selpercatinib |
411; 297; 340; 336 | — |
| PRIMARY PK: Mean Residence Time (MRT) of Selpercatinib |
25.5; 23.3; 24.2; 34.3 | — |
| PRIMARY Number of Participants With One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration |
0; 0; 0; 0 | — |
Eligibility Criteria
Inclusion Criteria
- Female participants of non-childbearing potential who are agreeable to take birth control measures until study completion
- Males who are capable of fathering a child must agree to use one of the following methods of contraception from the time of the dose administration through 6 months after dose administration:
- Male sterilization, with documented confirmation of surgical success. Male subjects will be surgically sterile for at least 90 days prior to Check-in (Day -1). If documentation is not available, male subjects must follow one of the contraception methods below:
- Male condom with spermicide, or
- For a female partner of male study participant:
- Intrauterine device (IUD) (hormonal IUD; eg, Mirena®). Copper IUDs are acceptable (eg, ParaGard®);
- Established use of oral, implanted, transdermal, or hormonal method of contraception associated with inhibition of ovulation; or
- Bilateral tubal ligation.
- Body mass index (BMI) ≥ 18.0 and ≤ 32.0 kilograms per meter squared (kg/m²) and had a minimum weight of at least 50 kg at screening
- Have normal blood pressure, pulse rate, electrocardiogram (ECG), and blood and urine laboratory test results that are acceptable for the study
Exclusion Criteria
- Are currently participating in or completed a clinical trial within the last 30 days or any other type of medical research judged to be incompatible with this study
- Have previously participated or withdrawn from this study
- Have or used to have health problems or laboratory test results or ECG readings that, in the opinion of the doctor, could make it unsafe to participate, or could interfere with understanding the results of the study
- Had blood loss of more than 500 milliliters (mL) within the previous 30 days of study screening
- Require treatment with inducers or inhibitors of cytochrome P450 (CYP) CYP3A within 14 days before the first dose of study drug through the end of treatment or early termination
Data sourced from ClinicalTrials.gov (NCT05436912). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.