N/A
Completed N=69
Reward Circuit Targeted iTBS
Transcranial Magnetic Stimulation
Source: ClinicalTrials.gov NCT05468853 ↗
Enrolled (actual)
69
Serious AEs
0.0%
Results posted
Jan 2026
Primary outcomePrimary: Change in Anhedonia Post-intervention and Washout — 6.4231; 5.4327 Scores on a scale — p=0.0452
Summary
The objective of this study is to examine the effect of intermittent theta-burst transcranial magnetic stimulation (iTBS) targeting the reward circuit.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Anhedonia Post-intervention and Washout |
6.4231; 5.4327 | 0.0452 sig |
| PRIMARY Change in Anhedonia Post-intervention |
5.8462; 4.75 | 0.1182 |
| PRIMARY Change in Anhedonia Post-washout |
7; 6.1154 | 0.1861 |
| PRIMARY Change in RewP Post-intervention and Washout Measured Via EEG |
0.2027; -0.3760 | 0.1380 |
| PRIMARY Change in RewP Post-intervention Measured Via EEG |
0.3579; -0.2191 | 0.1969 |
| PRIMARY Change in RewP Post-washout Measured Via EEG |
0.0475; -0.5328 | 0.2536 |
| SECONDARY Change in Reward Activation Measured Via fMRI |
-0.1067; -0.0702 | 0.71946 |
| SECONDARY Change in Reward Connectivity Measured Via fMRI |
-0.0463; 0.0049 | 0.19941 |
Eligibility Criteria
Inclusion Criteria
- Right-handed
- Native English speaker or fluent by the age of 6
- Elevated self-reported anhedonia
Exclusion Criteria
- Left-handed
- Metal in head
- Brain tumor, stroke, aneurysm, multiple sclerosis
- Active substance use disorder in last 3 months
- Dementia or other cognitive disorder making unable to engage in treatment
- History or diagnosis of schizophrenia, schizoaffective disorder, delusional disorder, or other psychiatic illness that precludes safe participation in trial
- Suicidal risk that precludes safe participation
- obsessive-compulsive disorder
- Inability to stop taking any mediation that significant lowers the seizure threshold (e.g. tricyclic antidepressants, clozapine, etc.)
- Severe traumatic brain injury
- Non-English speaker
Data sourced from ClinicalTrials.gov (NCT05468853). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.