N/A N=196 Randomized Quadruple-blind Treatment

Effect of a Multivitamin Supplement With Probiotic (Seidivid Ferty4®) on Oocyte Retrieval and Quality

Reproductive Techniques, Assisted

Bottom Line

View on ClinicalTrials.gov: NCT05473039 ↗

Enrolled (actual)

196

Serious AEs

0.0%

Results posted

Aug 2025

Primary outcome: Primary: Number of Oocytes Retrieved — 24.77; 22.57 oocytes retrieved — p=0.2629

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Seidivid Ferty4 (Dietary_supplement); Placebo (Other)
Age: Adult · 18+ yrs
Sex: Female
Sponsor: SEID S.A.
Primary completion: Jul 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Oocytes Retrieved	24.77; 22.57	0.2629
PRIMARY Number of Mature (MII) Oocytes Retrieved	20.41; 18.86	0.3582
SECONDARY Number of Good Quality Oocytes	17.00; 15.43	0.2187
SECONDARY Number of Oocytes With Dimorphisms	3.71; 3.46	0.3005
SECONDARY Number of Follicles at the Time of Trigger Administration	28.01; 24.8	0.0314 sig
SECONDARY Fasting Glucose After 30 Days of Treatment With Dietary Supplement.	81.49; 82.48	0.9214
SECONDARY AST After 30 Days of Treatment With Dietary Supplement.	20.38; 20.37	0.59695
SECONDARY ALT After 30 Days of Treatment With Dietary Supplement.	19.14; 16.84	0.062810
SECONDARY Cholesterol After 30 Days of Treatment With Dietary Supplement.	167.89; 170.17	0.686488
SECONDARY LH at the Time of COH Start	6.55; 5.69	0.257496

Summary

This study evaluates the effect of pretreatment with a multivitamin supplement with probiotics (Seidivid Ferty4®) on oocyte retrieval in normo-responder patients undergoing controlled ovarian hyperstimulation (COH) for oocyte donation, considering both the total number of oocytes retrieved and the number of mature oocytes retrieved, that is, in metaphase II (MII).

Eligibility Criteria

Inclusion Criteria

Women undergoing COH for egg donation cycles
Signing of Informed Consent
Age 18-34 years
Body mass index between 18-29.9 kg/m2
Meet the criteria for inclusion in the oocyte donation program of the Next Fertility center
Ultrasound antral follicle count before COH of ≥15 follicles

Exclusion Criteria

Patients excluded from the oocyte donation program
Untreated sexually transmitted disease, HIV, HCV, HBV positive serology
Blood disorders, neurodegenerative/psychiatric diseases, fragile X syndrome, oncological diseases, endometriosis.
Polycystic ovary syndrome
Oligomenorrhea (<1 menstrual cycle in 3 months)
Diabetic patients

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05473039). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.