Phase 4
Completed N=115
Reducing Hypotensive Anesthesia Use With TXA During Orthognathic Surgery
Hypotension During Surgery · Blood Loss, Surgical
Source: ClinicalTrials.gov NCT05474027 ↗
Enrolled (actual)
115
Serious AEs
0.0%
Results posted
May 2026
Primary outcomePrimary: Surgeon's Analysis of Surgical Field Visualization — 1.3 score on a scale
◆ Published Evidence
Not yet cited
0citations
Is Tranexamic Acid Associated With a Reduced Need for Hypotensive Anesthesia During Orthognathic Surgery?
Summary
This prospective study will analyze the need for deliberate hypotensive anesthesia (DHA) during orthognathic surgery when tranexamic acid (TXA) is administered. DHA has been proven to be effective although it comes with multiple risks related to organ hypoperfusion including kidney injury, stroke, and cardiac ischemia. Therefore, it may be potentially safer for patients to avoid deliberate hypotensive anesthesia if TXA alone adequately controls blood loss and provides adequate surgical site visualization.
Linked Publications
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Is Tranexamic Acid Associated With a Reduced Need for Hypotensive Anesthesia During Orthognathic Surgery?
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Surgeon's Analysis of Surgical Field Visualization |
1.3 | — |
| PRIMARY Percentage of Hours to Maintain a Mean Arterial Pressure |
14.3 | — |
| PRIMARY Average Volume of Blood Loss on a Scale |
1.3 | — |
Eligibility Criteria
Inclusion Criteria
- Bimaxillary orthognathic surgery completed at UAB Highlands Hospital
Exclusion Criteria
- History of hypertension or previously diagnosed cardiac problems
- Bleeding diathesis
- TXA medically contraindicated
Data sourced from ClinicalTrials.gov (NCT05474027) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.