Phase 4
Completed N=60
Efficacy of Trypsin-Chymotrypsin On Post-operative Pain After Single Visit Root Canal Treatment
Effect of Drug
Source: ClinicalTrials.gov NCT05479747 ↗
Enrolled (actual)
60
Serious AEs
0.0%
Results posted
Mar 2024
Primary outcomePrimary: Effect of Trypsin-Chymotrypsin on Post-operative Pain After Single Endodontic Treatment in Teeth With Symptomatic Irreversible Pulpitis — 3.47; 3.53; 2.93; 6.13 score on a scale
◆ Published Evidence
Emerging
8citations · ~3 / year
The Effect of Trypsin-Chymotrypsin on Postoperative Pain after Single Visit Endodontic Treatment: A Randomized Controlled Trial.
Summary
Achieving effective pain control after endodontic treatment is still a disruptive event to all the clinicians. There is a knowledge gap regarding the effect of protease on postoperative pain following root canal treatment, therefore, the efficacy of Trypsin-Chymotrypsin on post endodontic pain was evaluated clinically in a randomized triple-blind trial.
Linked Publications
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The Effect of Trypsin-Chymotrypsin on Postoperative Pain after Single Visit Endodontic Treatment: A Randomized Controlled Trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Effect of Trypsin-Chymotrypsin on Post-operative Pain After Single Endodontic Treatment in Teeth With Symptomatic Irreversible Pulpitis |
3.47; 3.53; 2.93; 6.13; 2; 1.87 | — |
| SECONDARY Synergistic Effect With NSAIDS |
3.47; 3.53; 2.93; 6.13; 2; 1.87 | — |
| SECONDARY Reported Side Effect |
0; 0; 0; 0; 0; 0 | — |
Eligibility Criteria
Inclusion criteria
- Egyptian healthy symptomatic both gender patients
- aged (18- 40) years old
- with no physical disability, facial paresthesia or psychological problems
- had mandibular first molars with symptomatic irreversible pulpitis and with normal appearance radiographically.
Exclusion criteria
- The vulnerable group
- participants who un abled to read and fill the questionnaire,
- those who took preoperative analgesics 24 h prior to treatment
- those with known sensitivity to the drugs used in this study
Data sourced from ClinicalTrials.gov (NCT05479747) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.