Phase 4
N=60
Efficacy of Trypsin-Chymotrypsin On Post-operative Pain After Single Visit Root Canal Treatment
Effect of Drug
Bottom Line
View on ClinicalTrials.gov: NCT05479747 ↗Enrolled (actual)
60
Serious AEs
0.0%
Results posted
Mar 2024
Primary outcome: Primary: Effect of Trypsin-Chymotrypsin on Post-operative Pain After Single Endodontic Treatment in Teeth With Symptomatic Irreversible Pulpitis — 3.47; 3.53; 2.93; 6.13 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- post operative analgesics (Drug)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Ain Shams University
- Primary completion
- Dec 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Effect of Trypsin-Chymotrypsin on Post-operative Pain After Single Endodontic Treatment in Teeth With Symptomatic Irreversible Pulpitis |
3.47; 3.53; 2.93; 6.13; 2; 1.87 | — |
| SECONDARY Synergistic Effect With NSAIDS |
3.47; 3.53; 2.93; 6.13; 2; 1.87 | — |
| SECONDARY Reported Side Effect |
0; 0; 0; 0; 0; 0 | — |
Summary
Achieving effective pain control after endodontic treatment is still a disruptive event to all the clinicians. There is a knowledge gap regarding the effect of protease on postoperative pain following root canal treatment, therefore, the efficacy of Trypsin-Chymotrypsin on post endodontic pain was evaluated clinically in a randomized triple-blind trial.
Eligibility Criteria
Inclusion criteria
- Egyptian healthy symptomatic both gender patients
- aged (18- 40) years old
- with no physical disability, facial paresthesia or psychological problems
- had mandibular first molars with symptomatic irreversible pulpitis and with normal appearance radiographically.
Exclusion criteria
- The vulnerable group
- participants who un abled to read and fill the questionnaire,
- those who took preoperative analgesics 24 h prior to treatment
- those with known sensitivity to the drugs used in this study
Data sourced from ClinicalTrials.gov (NCT05479747). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.