N/A N=12 Single-blind Basic Science

Central Sodium Sensing: Implications for Blood Pressure Regulation

Salt Sensitivity of Blood Pressure

Bottom Line

View on ClinicalTrials.gov: NCT05480722 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Dec 2025

Primary outcome: Primary: Functional Connectivity Between the Subfornical Organ and Organum Vasculosum of the Lamina Terminalis (Z-score) — 0.258490; 0.359145; 0.207372; 0.169055 z-score

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Hypertonic Saline with furosemide (Other); Hypertonic Saline without furosemide (Other)
Age: Adult · 18+ yrs
Sex: All
Sponsor: University of Delaware
Primary completion: Jan 2025

Outcome Measures

Outcome	Result	p-value
PRIMARY Functional Connectivity Between the Subfornical Organ and Organum Vasculosum of the Lamina Terminalis (Z-score)	0.258490; 0.359145; 0.207372; 0.169055; 0.272881; 0.097043	—

Summary

The ability of the brain to sense changing sodium levels in the blood is critical in mediating the neurohumoral responses to hypernatremia, however, the mechanisms underlying sodium sensing in humans is poorly understood. The purpose of this study is to identify key sodium-sensing regions of the human brain in older adults and determine if the Na-K-2Cl co-transporter mediates the neurohumoral response to acute hypernatremia. Completion of this project will increase our understanding of blood pressure regulation, which has major public health implications.

Eligibility Criteria

Inclusion Criteria

Age: 18 - 45 years
Blood pressure: >100/60 mmHg and 45 years
Blood pressure: 130/80 mmHg
BMI: 30 kg/m2
Serum potassium: 5.5 mmol/L
Abnormal ECG
History of - cardiovascular, cancer, metabolic, respiratory, renal disease
Hormone replacement therapy
Current tobacco or nicotine use
Pregnant or nursing mothers
Major brain injury (concussions do not count)
Clinically diagnosed psychiatric or neurological disorder
Clinically diagnosed anxiety or depression
Psychiatric, neurological, anxiety or depression medications
Hypertension medications
Sulfonamide drug allergy

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05480722). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.