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N/A N=206

Prevalence of Thiamine Deficiency in Hospitalized Non-Alcoholic Veterans

Thiamine Deficiency · Thiamine Deficiency; Sequelae

Enrolled (actual)
206
Serious AEs
0.0%
Results posted
Oct 2025
Primary outcome: Primary: Percentage of Participants With Thiamine Deficiency (Low Plasma Thiamine) Out of Total Number of Enrolled Veterans With Plasma Thiamine Results — 49 Participants

Study Design & Population

Study type
Observational
Phase
N/A
Interventions
Thiamine repletion (Dietary_supplement)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
VA Office of Research and Development
Primary completion
Sep 2024

Outcome Measures

OutcomeResultp-value
PRIMARY
Percentage of Participants With Thiamine Deficiency (Low Plasma Thiamine) Out of Total Number of Enrolled Veterans With Plasma Thiamine Results
49
SECONDARY
Association of Thiamine Deficiency and Inflammation
8; 25 0.6097
SECONDARY
Cut-point Analysis of Thiamine Biomarkers

Summary

Thiamine micronutrient deficiency (TD) can cause a variety of non-specific symptoms and leads to several thiamine deficiency disorders such as heart failure, polyneuropathy, Wernicke's Encephalopathy and generalized weakness and debility. Symptoms are often vague and non-specific such as fatigue, leg swelling, imbalance, confusion, mood disorders, gastrointestinal upset, and weakness. Hospitalized Veterans may be particularly susceptible to TD due to food insecurity and chronic illnesses which cause inflammation and increased metabolic demands. This study aims to determine the prevalence of TD in hospitalized Veterans which has never been done before. The investigators also seek to identify risk factors causing TD including acute and chronic forms of inflammation, food insecurity, and dietary habits. Lastly, the investigators hope to clarify the abnormally low levels of blood thiamine that correlate with symptoms of TD that improve with replenishment.

Eligibility Criteria

Inclusion Criteria

  • full admission to the hospital medical service (not on observation status)

Exclusion Criteria

  • excess alcohol intake as defined by the National Institute of Alcohol Abuse and Alcoholism
  • taking thiamine supplement
  • quadriplegic
  • lives more than 75 miles from the medical center
  • unable to demonstrate capacity to understand the study and provide informed consent
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05480943). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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