N/A
Completed N=774
Implementation of a Combination Intervention for Sustainable Blood Pressure Control
Source: ClinicalTrials.gov NCT05492955 ↗Enrolled (actual)
774
Serious AEs
1.7%
Results posted
Mar 2026
Primary outcomePrimary: Mean Systolic Blood Pressure (SBP) Change — -1.9; -9.1; -10.5 mmHg — p=<0.001
Summary
This is a randomized clinical trial intended to identify the optimal strategy of blood pressure management in rural South Africa using Community Health Workers (CHWs) in conjunction with in-home BP monitoring among adults.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Systolic Blood Pressure (SBP) Change |
-1.9; -9.1; -10.5 | <0.001 sig |
| SECONDARY Percentage of Participants With Blood Pressure Control (%) |
32.5; 57.4; 61.3 | 0.025 sig |
Eligibility Criteria
Inclusion Criteria
- Age greater than 18 years old
- Residing in uMkhanyakude District in northern KwaZulu-Natal in an area that is served by a CHW.
- Elevated blood pressure (blood pressure > 140/90 mmHg) on two measurements.
Exclusion Criteria
- Pregnant or breast-feeding women.
- Severe, symptomatic hypertension with a measured blood pressure > 180/110 mmHg.
- Known, advanced chronic kidney disease. GFR < 60 ml/min/1.73 m2.
- Current use of at least 3 different anti-hypertensive therapies at full dose.
- Planning to move within the next 24 months.
Data sourced from ClinicalTrials.gov (NCT05492955). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.