N/A N=60 Randomized Treatment

The Effects of Intensity on Exercise-Induced Hypoalgesia During a Knee Extension Exercise

Healthy

Bottom Line

View on ClinicalTrials.gov: NCT05561582 ↗

Enrolled (actual)

Serious AEs

—

Results posted

Dec 2024

Primary outcome: Primary: Pressure Pain Threshold — 19.11; 48.22; -4.14 kilopascals

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Seated knee extension exercise (Other)
Age: Adult · 18+ yrs
Sex: All
Sponsor: University of Central Florida
Primary completion: Mar 2023

Outcome Measures

Outcome	Result	p-value
PRIMARY Pressure Pain Threshold	19.11; 48.22; -4.14	—
SECONDARY Conditioned Pain Modulation	-34.44; -21.41; -54.03	—

Summary

The primary purpose of this study is to to compare immediate changes in pressure pain threshold at the exercising muscle (quadriceps) and a non-exercising muscle (upper trapezius) during low and high weight knee extension exercise. Participants will attend one session that consists of pain sensitivity testing, completion of pain-related psychological questionnaires, and random assignment to one of three interventions: 1) knee extension exercise with a high weight, 2) knee extension exercise with a low weight, or 3) quiet rest.

Eligibility Criteria

Inclusion Criteria

Pain-free
18-60 years old
Participant can appropriately perform the knee extension exercise (assessed during screening)

Exclusion Criteria

Non-English speaking
Regular use of prescription pain medications
Current or history of chronic pain condition
Currently taking blood-thinning medication
Systemic medical condition known to affect sensation, such as uncontrolled diabetes or neurological conditions
Any contraindication to the application of ice, such as: uncontrolled hypertension, cold urticaria, cryoglobulinemia, paroxysmal cold hemoglobinuria, circulatory compromise
Known presence of cardiovascular, pulmonary, or metabolic disease
Current use of tobacco products
Not physically ready to exercise without a medical exam as indicated by the Physical Activity Readiness Questionnaire Plus (PAR-Q+)
Surgery, injury, or fracture to the lower back or lower extremity within the past 6 months

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Data sourced from ClinicalTrials.gov (NCT05561582). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.