N/A N=24 Randomized Basic Science

Causal Role of Frontostriatal Circuitry in Goal-directed Behavior

Executive Function

Bottom Line

View on ClinicalTrials.gov: NCT05593965 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jul 2024

Primary outcome: Primary: Percentage of the Trials That the Participant Chooses to Perform the Hard Task — 33.2; 32.9; 33.6; 37.1 Percentage of trials

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Delta-beta TMS (Device); Theta-gamma TMS (Device); Arrhythmic TMS (Device)
Age: Adult · 18+ yrs
Sex: All
Sponsor: University of North Carolina, Chapel Hill
Primary completion: Jul 2023

Outcome Measures

Outcome	Result	p-value
PRIMARY Percentage of the Trials That the Participant Chooses to Perform the Hard Task	33.2; 32.9; 33.6; 37.1; 37.1; 37.6	—
SECONDARY Coupling Strength Between Low-frequency Prefrontal Signals and High-frequency Posterior Signals	0.416; 0.008; 0.308; -0.051; -0.094; 0.274	—

Summary

The purpose of this clinical trial is to investigate the causal role that frontostriatal circuitry plays in goal-directed behavior. The participants will perform a reward-based decision-making task. During the task, cross-frequency patterned rhythmic transcranial magnetic stimulation (TMS) will be delivered at delta-beta frequency, a control-frequency, or an active sham to either the dorsolateral or medial prefrontal cortex (PFC). Electroencephalography will be collected concurrent with stimulation. Structural and functional magnetic resonance imaging (MRI) will be collected during performance of the reward-based decision-making task to localize the stimulation targets.

Eligibility Criteria

Inclusion Criteria

Healthy
Between the ages of 18 and 35
Right handed
Able to provide informed consent
Willing to comply with all study procedures
Available for the duration of the study
Speak and understand English.

Exclusion Criteria

Attention Deficit Hyperactivity Disorder (currently under treatment)
Neurological disorders and conditions, including, but not limited to: History of epilepsy Seizures (except childhood febrile seizures)
Dementia
History of stroke
Parkinson's disease
Multiple sclerosis
Cerebral aneurysm
Brain tumors
Medical or neurological illness or treatment for a medical disorder that could interfere with study participation (e.g., unstable cardiac disease, human immunodeficiency virus or acquired immunodeficiency syndrome, malignancy, liver or renal impairment)
Prior brain surgery
Any brain devices/implants, including cochlear implants and aneurysm clips
Cardiac pacemaker
Any other implanted electronic device
History of current traumatic brain injury
(For females) Pregnancy or breast feeding
Anything that, in the opinion of the investigator, would place the participant at increased risk or preclude the participant's full compliance with or completion of the study

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05593965). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.