N/A N=58,364 Randomized Health Services Research

Dissemination and Implementation of Improving Pediatric Obesity Practice Using Prompts

Obesity, Childhood

Bottom Line

View on ClinicalTrials.gov: NCT05627011 ↗

Enrolled (actual)

58,364

Serious AEs

—

Results posted

Mar 2026

Primary outcome: Primary: Mean Change in BMI as Percentage of 95th Percentile — -0.60; -0.34 percentage — p=<0.0001

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Improving Pediatric Obesity Practice Using Prompts (iPOP-UP) (Behavioral)
Age: Pediatric, Adult, Older Adult · 2+ yrs
Sex: All
Sponsor: Yale University
Primary completion: Dec 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Mean Change in BMI as Percentage of 95th Percentile	-0.60; -0.34	<0.0001 sig
PRIMARY Percent Adherence in Composite Measure of Clinician's Adherence to Clinical Guidelines, for Visits Completed Among Children 2-18 Years-old With BMI ≥85th Percentile.	1.78; 1.24	0.016 sig
SECONDARY Percent Adherent Visits in Composite Measure of Clinician's Adherence to Clinical Guidelines	1.73; 0.95; 2.04; 1.5	<.0001 sig
SECONDARY Percent Visits With Inclusion of Diagnosis Code Indicating High BMI in Problem List	29.75; 22.39; 29.76; 21.61; 33.02; 22.29	<.0001 sig
SECONDARY Percent Visits With Inclusion of Diagnosis Code Indicating High BMI in Visit Diagnosis	53.37; 51.51; 44.85; 42.72; 52.48; 48.96	0.34
SECONDARY Percent Adherent Visits to Guideline Recommended Screening Lab Orders for Obesity Related Comorbidities, if Eligible	36.98; 30.22; 39.26; 32.94; 39.88; 31.52	<.0001 sig
SECONDARY Percent Adherent Visits in Appropriate Blood Pressure Screening	95.40; 95.05; 93.03; 91.96; 95.61; 94.73	0.65
SECONDARY Percent Adherent Visits in Structured Documentation of Counseling	17.74; 15.33; 14.51; 12.40; 17.70; 14.08	0.011 sig
SECONDARY Percent Visits With Follow-up Visit Requested	5.50; 5.37; 5.14; 5.92; 4.70; 5.04	0.83
SECONDARY Percent Visits With Referral for Further Management of Obesity	11.09; 9.18; 10.93; 8.32; 10.50; 8.94	0.013 sig
SECONDARY Percent Visits With Weight Loss Medication Orders, if Eligible	5.91; 6.06; 6.17; 6.35; 4.74; 6.31	0.83
SECONDARY Percent Visits With Bariatric Surgery Program Referrals, if Eligible	0.07; 0.14; 0.04; 0.10; 0.06; 0.09	—
SECONDARY Percent Change in Potentially Unnecessary Insulin or Thyroid Laboratory Tests Ordered	25.37; 27.30; 28.43; 27.86; 26.05; 24.59	0.23
SECONDARY Percent Visits With Clinicians' Utilization of the Clinical Decision Support Tools	6.81; 5.97; 6.12	—
SECONDARY Mean Change in Clinicians' Attitudes and Practice Around Managing Elevated BMI in Primary Care	0.0277; 0.1320; 0.3598; -0.0340; 0.0879; -0.2312	0.9556
SECONDARY Total Cost and Cost-effectiveness of iPOP-UP	107023	—

Summary

The purpose of this study is to evaluate the dissemination and implementation of electronic health record-based clinical decision support tools for the management of pediatric overweight and obesity in primary care.

Eligibility Criteria

Inclusion Criteria

Primary Care Practices: all primary care practices using the EHR system of one of the 3 health systems participating in the study that agree to participate in the iPOP-UP trial;
Clinician-participants: all clinicians who delivery pediatric primary care at the participating practices, including physicians and physicians-in-training (residents and fellows), physician assistants (PA), nurse practitioners (NP)/advanced practice registered nurses (APRNs);
Patient-participants: all patients ages 2-18 with overweight/obesity seen during the study period may be impacted by the intervention. A limited dataset will be collected for the subset of these 2 to 18 years old patients with BMI ≥ 85th percentile for age and sex seen for a well or follow-up visit during the study period in a primary care department and conducted by a prescribing clinician (physician, NP, PA)

Exclusion Criteria

None - exclusion criteria are purposefully limited in this real-world implementation study

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05627011). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.