N/A
Completed N=6
Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder (Pilot Study)
Source: ClinicalTrials.gov NCT05631548 ↗Enrolled (actual)
6
Serious AEs
0.0%
Results posted
Jan 2024
Primary outcomePrimary: Amplitude of the Reward Potential (RewP) in Microvolts in Response to Feedback on the Doors Task as Assessed by EEG — -1.09; 0.61; -0.23; 0.12 microvolts
Summary
The purpose of this study is to assess the effects of active intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal cortex (dmPFC) on electroencephalogram (EEG) measures of reward sensitivity and cue reactivity and cocaine craving in cocaine users
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Amplitude of the Reward Potential (RewP) in Microvolts in Response to Feedback on the Doors Task as Assessed by EEG |
-1.10; 0.21; -1.30; 0.02 | — |
| PRIMARY Amplitude of the Reward Potential (RewP) in Microvolts in Response to Feedback on the Doors Task as Assessed by EEG |
-1.10; 0.21; -1.30; 0.02 | — |
| PRIMARY Amplitude of the Late Positive Potential (LPP) in Microvolts in Response to Visual Stimuli on the Picture Viewing Task as Assessed by EEG |
.66; .19; 1.11; .78; 1.02; .43 | — |
| PRIMARY Amplitude of the Late Positive Potential (LPP) in Microvolts in Response to Visual Stimuli on the Picture Viewing Task as Assessed by EEG |
.66; .19; 1.11; .78; 1.02; .43 | — |
| SECONDARY Craving as Assessed by the Minnesota Cocaine Craving Scale (MCCS) |
33.8; 18 | — |
| SECONDARY Craving as Assessed by the Minnesota Cocaine Craving Scale (MCCS) |
33.8; 18 | — |
| SECONDARY Pain as Assessed by the Visual Analog Scale (VAS) |
2; 1.6 | — |
| SECONDARY Pain as Assessed by the Visual Analog Scale (VAS) |
2; 1.6 | — |
| SECONDARY Cognitive Function as Assessed by the Montreal Cognitive Assessment (MoCA) |
23; 22.8 | — |
| SECONDARY Cognitive Function as Assessed by the The Montreal Cognitive Assessment (MoCA) |
22.4; 25 | — |
Eligibility Criteria
Inclusion Criteria
- CUD diagnosis
Exclusion Criteria
- moderate or severe criteria for substances other than cocaine, cannabis, or nicotine
- unstable psychiatric disorder
- medical conditions contraindicated to TMS (e.g., medical implants, history of seizure or seizure disorder, medications lowering the seizure threshold, neurological conditions, moderate-to-severe heart disease)
- pregnancy
- hairstyles incompatible with the EEG net
- head injury with loss of consciousness
Data sourced from ClinicalTrials.gov (NCT05631548). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.