N/A
N=17
Effects of Radiofrequency Ablation of Posterior Nasal Nerves on Inflammatory Cytokines, Peak Nasal Inspiratory Flow, and Nasal Blood Flow in Patients With Chronic Rhinitis
Chronic Rhinitis
Bottom Line
View on ClinicalTrials.gov: NCT05648565 ↗Enrolled (actual)
17
Serious AEs
0.0%
Results posted
Apr 2025
Primary outcome: Primary: Nasal Congestion as Assessed by the Peak Nasal Inspiratory Flow (PNIF) — 90 Liters Per Minute
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Radiofrequency ablation (RFA) (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- The University of Texas Health Science Center, Houston
- Primary completion
- Feb 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Nasal Congestion as Assessed by the Peak Nasal Inspiratory Flow (PNIF) |
85 | — |
| PRIMARY Nasal Congestion as Assessed by the Peak Nasal Inspiratory Flow (PNIF) |
85 | — |
| PRIMARY Nasal Congestion as Assessed by the Peak Nasal Inspiratory Flow (PNIF) |
85 | — |
| PRIMARY Interleukin-10 (IL-10) |
9.05 | — |
| PRIMARY Interleukin-22 (IL-22) |
0.37 | — |
| PRIMARY Interleukin-10 (IL-10) |
9.05 | — |
| PRIMARY Interleukin-22 (IL-22) |
0.37 | — |
| SECONDARY Nasal Congestion as Assessed by the Reflective Total Nasal Symptom Score (rTNSS) |
4 | — |
| SECONDARY Nasal Congestion as Assessed by the Reflective Total Nasal Symptom Score (rTNSS) |
4 | — |
| SECONDARY Nasal Congestion as Assessed by the Reflective Total Nasal Symptom Score (rTNSS) |
4 | — |
| SECONDARY Nasal Obstruction as Assessed by the Nasal Obstruction Symptom Evaluation Survey (NOSE) |
17.5 | — |
| SECONDARY Nasal Obstruction as Assessed by the Nasal Obstruction Symptom Evaluation Survey (NOSE) |
17.5 | — |
| SECONDARY Nasal Obstruction as Assessed by the Nasal Obstruction Symptom Evaluation Survey (NOSE) |
17.5 | — |
Summary
The purpose of this study is to assess the effectiveness of radiofrequency ablation (RFA) of the posterior nasal nerve (PNN) in chronic rhinitis (CR) patients by comparing patient reflective total nasal symptom score (rTNSS) and nasal obstruction symptom evaluation (NOSE) , peak nasal inspiratory flow (PNIF) , and levels of Type 2 cytokines pre- and post-procedure.
Eligibility Criteria
Inclusion Criteria
- chronic rhinitis symptoms for at least 6 months (rhinorrhea, congestion, post-nasal drip)
- poor response to medical management that was attempted for at least 4 weeks
- a rTNSS score ≥6, as well as ≥2 for rhinorrhea, and ≥1 for congestion.
Exclusion Criteria
- active sinusitis
- rhinitis medicamentosa
- recurrent and ongoing epistaxis
- immunodeficiency as defined by an illness or a history of sinus surgery.
Data sourced from ClinicalTrials.gov (NCT05648565). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.