N/A
Completed N=203
Postoperative Cognitive Dysfunction as Geriatric Syndrome
Source: ClinicalTrials.gov NCT05648890 ↗Enrolled (actual)
203
Serious AEs
—
Results posted
Feb 2025
Primary outcomePrimary: Postoperative Cognitive Dysfunction - Results of MMSE Before Operation — 79; 43; 37; 5 Participants — p=<0.0001
Summary
This study is testing cognitive function before and after the surgery, with patient's informed consent. Patients of interest are 65 year or older, undergoing surgery in general or regional anesthesia.
Investigators are using 3 tests. These are: MMSE (Mini Mental State Exam), TEGEST test (test of gestures) and Clock drawing test.
Tests after surgery are performed 2 days until discharge. The testing is anonymous, patient is assigned a number. Main aim of this study is to find a suitable quick test of cognitive function for clinical practice before surgery in general or regional anesthesia.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Postoperative Cognitive Dysfunction - Results of MMSE Before Operation |
79; 43; 37; 5 | <0.0001 sig |
| PRIMARY Postoperative Cognitive Dysfunction - Results of MMSE After Operation |
77; 43; 38; 6 | < .001 sig |
| PRIMARY Postoperative Cognitive Dysfunction - TEGEST Test Before Operation |
40; 124 | <0.0001 sig |
| PRIMARY Postoperative Cognitive Dysfunction - TEGEST Test After Operation |
77; 87 | <0.001 sig |
| PRIMARY Postoperative Cognitive Dysfunction -Clock Drawing Test Before Operation |
21; 143 | <0.001 sig |
| PRIMARY Postoperative Cognitive Dysfunction - Clock Drawing Test After Operation |
21; 143 | <0.0001 sig |
| SECONDARY Clinical Frailty Scale Before Operation |
9; 43; 24; 23; 24; 22 | <0.0001 sig |
| SECONDARY Social Anamnesis Before Operation- Type of Accommodation |
100; 40; 24 | .562 |
| SECONDARY Social Anamnesis During Preanesthesia Exam - Living Situation |
118; 46 | 0.129 |
| SECONDARY Social Anamnesis - Stairs or Elevator |
53; 111 | 0.019 sig |
Eligibility Criteria
Inclusion Criteria
- age 65 or older
- absence of sensory impairment (deafness)
- full legal capacity
- informed consent
- ability to speak
- elective or acute surgical procedure
Exclusion Criteria
- somnolence, coma
- sepsis
- Glasgow coma scale 14 and less
- known psychiatric disease
- effect of premedication, drugs
Data sourced from ClinicalTrials.gov (NCT05648890). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.