Phase 4
Completed N=150
ESP Block for Post Cesarean Analgesia
Cesarean Section Complications
Source: ClinicalTrials.gov NCT05664958 ↗
Enrolled (actual)
150
Serious AEs
0.0%
Results posted
Feb 2025
Primary outcomePrimary: Postoperative Oxycodone Consumption 0- 48 Hours After Cesarean Delivery — 12.5; 25 mg
◆ Published Evidence
Emerging
2citations · ~2 / year
Erector spinae plane block with liposomal bupivacaine for post-cesarean analgesia.
Summary
The purpose of this pilot study is to assess the analgesic efficacy of Erector Spinae Plane block (ESPB) with liposomal bupivacaine in women undergoing cesarean delivery and receiving a postoperative multimodal analgesic regimen as assessed by the dose of rescue postoperative opioids compared to a historical control group of women receiving the same multimodal regimen but with no truncal blocks. This will be a case control study with a prospective and a retrospective component. Women undergoing elective cesarean delivery under spinal or combined spinal epidural anesthesia will be approached to participate in the prospective open label component of the study. Cases will be matched in a 1:4 ratio by age, race, history of prior cesarean delivery, and insurance status with historical controls who received the same multimodal analgesic regimen but no truncal blocks. We plan to enroll 30 subjects for the prospective arm of the study and 120 for the retrospective arm.
Linked Publications
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Erector spinae plane block with liposomal bupivacaine for post-cesarean analgesia.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Postoperative Oxycodone Consumption 0- 48 Hours After Cesarean Delivery |
12.5; 25 | — |
| SECONDARY Postoperative Opioid Consumption at 24 Hours |
7.5; 15 | — |
| SECONDARY Time to First Postsurgical Opioid Rescue Medication |
12.2; 3.2 | — |
| SECONDARY Area Under the Curve (AUC) of Verbal Rating Scale (VRS) Pain Intensity Scores |
115; 140 | — |
| SECONDARY Number of Participants With Postoperative Nausea and Vomiting |
12 | — |
| SECONDARY Number of Participants With the Need for Rescue Antiemetics |
8; 48 | — |
| SECONDARY Number of Participants With Pruritus |
21 | — |
| SECONDARY Number of Participants With the Need for Rescue Antipruritics |
5; 30 | — |
| SECONDARY Number of Participants Not Receiving Any Rescue Opioids Postoperatively |
6; 27 | — |
Eligibility Criteria
Inclusion Criteria
- Patients ≥18 years of age with a term pregnancy of 37 to 42 weeks and American Society of Anesthesiologists Physical Status Classification II or III scheduled to undergo elective CD.
Exclusion Criteria
- ≥3 prior CDs, pre-pregnancy body mass index >40 kg/m2, planned concurrent surgical procedure other than tubal ligation, chronic pain or chronic opioid therapy, any clinically significant event or condition uncovered during surgery (eg, excessive bleeding, acute sepsis) that might render the patient medically unstable or complicate the patient's postsurgical course, or allergy or contraindication to any component of the multimodal analgesic regimen.
Data sourced from ClinicalTrials.gov (NCT05664958) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.