N/A Completed N=30

Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP

Nasal polyps · Aspirin-exacerbated Respiratory Disease

Source: ClinicalTrials.gov NCT05672030 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Nov 2025

Primary outcomePrimary: Number of Participants With Nasal Polyp Plasma Cell Transcriptome — 10; 10; 10 Participants

Summary

The overarching hypothesis of this proposal is that IL-5 acts on multiple sinus tissue cell types, including plasma cells and epithelial cells, to promote immune dysregulation, and that inhibition of IL-5 affects several relevant effector pathways that lead to clinical benefit.

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Participants With Nasal Polyp Plasma Cell Transcriptome	10; 10; 10	—
SECONDARY Number of Participants With Functional Readouts of IL-5Ra on Nasal Polyp Plasma Cells.	10; 10; 10	—
SECONDARY Number of Patients for Whom IL-5Ra Signaling on Nasal Epithelial Cells Can be Analyzed	10; 10; 10	—

Eligibility Criteria

Inclusion Criteria

AERD, CRSwNP, healthy controls

Exclusion Criteria

Not on any systemic steroids or respiratory biologics at time of surgery

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05672030). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.