N/A
Completed N=24
Brain Stimulation and Meditation for Pain After Total Knee Arthroplasty
Osteoarthritis, Knee
Source: ClinicalTrials.gov NCT05673720 ↗
Enrolled (actual)
24
Serious AEs
0.0%
Results posted
Nov 2025
Primary outcomePrimary: Analgesic Consumption — 0; 0 mg
Summary
Feasibility, acceptability, and preliminary efficacy of combined transcranial direct current stimulation and mindfulness for pain after total knee arthroplasty
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Analgesic Consumption |
0; 0 | — |
| SECONDARY Numerical Rating Scale (NRS) |
6.18; 5.71 | — |
| SECONDARY Brief Pain Inventory (BPI) |
6.04; 5.51 | — |
| SECONDARY Patient Health Questionnaire-4 (PHQ-4) |
5.4; 8.0 | — |
| SECONDARY Pain Catastrophizing Scale (PCS) |
20.56; 25.25 | — |
Eligibility Criteria
Inclusion Criteria
- elective unilateral knee total replacement
- mentally capable of reading, giving consent and following instructions
- being able to answer questions in English
- not pregnant
Exclusion Criteria
- history of brain surgery, brain tumor, seizure, stroke, or intracranial metal implantation
- systemic rheumatic disorders, including rheumatoid arthritis, systemic lupus erythematosus, and fibromyalgia
- alcohol/substance abuse
- current use of sodium channel blockers, calcium channel blockers and NMDS receptor antagonists
- hospitalization within the preceding year for psychiatric illness
- no access to a device with internet access that can be used for secure videoconferencing for real-time remote supervision
Data sourced from ClinicalTrials.gov (NCT05673720). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.