N/A
N=40
Effect of Waterpipe Size on Smoking Behavior and Exposures
Waterpipe Size
Bottom Line
View on ClinicalTrials.gov: NCT05705375 ↗Enrolled (actual)
40
Serious AEs
0.0%
Results posted
Nov 2025
Primary outcome: Primary: Waterpipe Evaluation Scale — 4.2; 4.4; 4.7 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Waterpipe size (Other)
- Age
- Adult · 21+ yrs
- Sex
- All
- Sponsor
- The University of Texas at Arlington
- Primary completion
- Feb 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Waterpipe Evaluation Scale |
4.2; 4.4; 4.7 | — |
| PRIMARY Duke Sensory Questionnaire |
4.4; 4.0; 3.8 | — |
| PRIMARY Harm Perception Questionnaire |
3.5; 3.7; 3.8 | — |
| PRIMARY Saliva Nicotine |
1065.5; 620.2; 701.4 | — |
| PRIMARY Puff Topography: Smoking Time |
38.05; 35.5; 36.27 | — |
| PRIMARY Puff Topography: Cumulative Puff Time |
5.10; 5.10; 6.67 | — |
| PRIMARY Puff Topography: Puff Duration |
2.15; 2.20; 2.45 | — |
| PRIMARY Puff Topography: Average Flow Rate |
15.14; 16.65; 18.92 | — |
| PRIMARY Puff Topography: Number of Puffs |
161.05; 162.31; 182.90 | — |
| PRIMARY Puff Topography: Total Smoke Volume Inhaled |
76.82; 79.85; 116.19 | — |
| PRIMARY Puff Topography: Puff Volume Average |
0.57; 0.64; 0.78 | — |
| PRIMARY Puff Topography: Maximum Puff Volume |
1.21; 1.34; 1.62 | — |
Summary
The goal of this clinical trial is to learn how waterpipe (WP) size affects smoking behavior, toxicant exposure, and subjective experiences in young adult WP smokers (ages 21-39). The main questions it aims to answer are:
* Does WP size change puffing behavior?
* Does WP size change exposure to nicotine and carbon monoxide?
* Does WP size change perceptions of harm, satisfaction, craving, or withdrawal?
Participants will smoke small, medium, and large WPs in separate sessions. Researchers will measure puffing behavior, saliva nicotine, exhaled carbon monoxide, and survey responses before and after each session.
Eligibility Criteria
Inclusion Criteria
- regular waterpipe smokers (smoking at least once a week for the past 6 months)
- generally healthy and
- able to provide written informed consent; and willing to attend the 3 lab sessions
Exclusion Criteria
- history of chronic diseases such as diabetes, high blood cholesterol, hepatic disease
- respiratory chronic diseases
- cardiovascular diseases including low or high blood pressure (BP)
Data sourced from ClinicalTrials.gov (NCT05705375). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.