N/A
Completed N=15
Modulation of Sensory Acuity With Transcranial Magnetic Stimulation (TMS)
Speech
Source: ClinicalTrials.gov NCT05723575 ↗
Enrolled (actual)
15
Serious AEs
0.0%
Results posted
Dec 2024
Primary outcomePrimary: Somatosensory Acuity: Spatial Amplitude Discrimination Threshold (SDT) — 20.08; -8.07; 5.39; -2.81 change in threshold (µm)
Summary
The purpose of this research study is to understand how the brain processes and controls speech in healthy people. The investigators are doing this research because it will help identify the mechanisms that allow people to perceive their own speech errors and to learn new speech sounds, which may be applied to people who have communication disorders. 15 participants will be enrolled into this part of the study and can expect to be on study for 4 visits of 2-4 hours each.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Somatosensory Acuity: Spatial Amplitude Discrimination Threshold (SDT) |
20.08; -8.07; 5.39; -2.81 | — |
| PRIMARY Somatosensory Acuity: Temporal Discrimination Threshold (TDT) |
0.41; 5.80; 4.54; -2.97 | — |
Eligibility Criteria
Inclusion Criteria (Control):
- English-speaking adults
- normal hearing and speech
- no history of stroke or neurological conditions
Exclusion Criteria
- Native language other than English
- Any neurological disorders other than the disorder of interest
- Any history of hearing disorders
- Uncorrected vision problems that prevent participants from seeing visually-presented stimuli
- Significant cognitive impairments that prevent participants from carrying out the task or from giving informed consent
- Vulnerable populations (minors and prisoners)
- Additional exclusionary criteria for TMS:
- Implanted paramagnetic materials (metal clips, plates, pacemakers, etc.)
- Increased risk in the event of a seizure
- Serious heart disease
- Increased intracranial pressure
- Pregnancy
- History of seizures
- Family history of epilepsy
- Epileptogenic medications
- Chronic or transient disruption of sleep (including jet lag)
- History of fainting
- Chronic or transient increase in stressful experiences
- Use of illegal drugs
Data sourced from ClinicalTrials.gov (NCT05723575). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.