N/A
Completed N=38
Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer
Bone Sarcoma · Childhood Cancer
Source: ClinicalTrials.gov NCT05746429 ↗
Enrolled (actual)
38
Serious AEs
0.0%
Results posted
Feb 2026
Primary outcomePrimary: Pain Intensity — -0.96; -0.56 Change in scores on a scale
Summary
This is a prospective study that will conduct a series of focus groups with non-Hispanic Black and Hispanic childhood cancer survivors to obtain their input on culturally adapting a mobile CBT program for chronic pain and tDCS procedures. Once this adaptation process is completed, the investigators will conduct a feasibility trial with non-Hispanic Black, Hispanic and non-Hispanic White survivors of childhood cancer with chronic pain. The feasibility study will assign eligible participants to either culturally adapted mobile CBT + active tDCS to the dorsolateral prefrontal cortex or culturally adapted mobile CBT + sham tDCS. We anticipate approximately 60 participants for the focus groups and approximately 30 participants for the feasibility study for a total of about 90 participants.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain Intensity |
-0.96; -0.56 | — |
| PRIMARY Pain Interference |
-0.60; -1.30 | — |
| PRIMARY Pain Catastrophizing |
-0.07; -1.13; -0.64; -0.69; 1.07; -1.81 | — |
| PRIMARY Depression |
-0.65; -3.13 | — |
| PRIMARY Anxiety |
-3.82; -2.01 | — |
| PRIMARY Cancer-related Worry |
3.64; -4.13 | — |
| PRIMARY Physical Functioning |
0.34; 4.03; 1.94; 0.42 | — |
| PRIMARY Peer Relations |
-1.64; -3.26 | — |
| PRIMARY Fatigue |
-2.72; -2.86 | — |
| PRIMARY Sleep (Adolescent Sleep Wake Scale (ASWS)) |
-0.20; 0.61 | — |
| PRIMARY Sleep (PROMIS Sleep-related Impairment) |
-0.51; -2.76 | — |
| PRIMARY Global Acceptability and Satisfaction With Treatment |
3; 10; 11; 6; 8; 12 | — |
| PRIMARY Opioid Use |
0; 0 | — |
| PRIMARY Parental Depression |
-2.00; -1.19 | — |
| PRIMARY Parental Anxiety |
-0.93; -1.14 | — |
Eligibility Criteria
Inclusions Criteria for cultural adaption
- Adult
- Hispanic or non-Hispanic Black childhood cancer survivor or parent of Hispanic or non-Hispanic Black childhood cancer survivor
- 18 years or older
- Adolescents
- 10-17 years-old survivors of childhood cancer
- At least one year post treatment
- Hispanic or non-Hispanic Black
- Phase 4 only: History of chronic pain (i.e. pain that was present for more than 3 months)
Exclusion Criteria for cultural adaptation
- Adults/Adolescents
- Inability or unwillingness of research participants or legal guardian/representative to give written informed consent
Inclusion Criteria for feasibility study
- Hispanic, non-Hispanic Black and non-Hispanic White 10-17-year-old survivors of pediatric cancer
- At least one year post treatment
- Pain present over the past 3 months and pain at least once per week
- Pain interfering with at least one area of daily functioning
Exclusion Criteria for feasibility study
- Limb amputation
- History of seizures or other neurological disorders
- Implanted medical device or metal in the head
- Serious comorbid psychiatric condition
- Current substance abuse
- History of development delay or significant cognitive impairment
- History of brain tumor diagnosis
Data sourced from ClinicalTrials.gov (NCT05746429). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.