N/A N=24 Treatment

A Study of Revian Red All LED Cap as a Novel Treatment for Central Centrifugal Cicatricial Alopecia

Central Centrifugal Cicatricial Alopecia

Bottom Line

View on ClinicalTrials.gov: NCT05759338 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Aug 2025

Primary outcome: Primary: Shape of the Hairline Documented With Photographs — 8; 12; 2 Participants

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Revian Red All LED cap (Device)
Age: Adult, Older Adult · 18+ yrs
Sex: Female
Sponsor: Wake Forest University Health Sciences
Primary completion: Jun 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Shape of the Hairline Documented With Photographs	8; 12; 2	—
SECONDARY Change in Hairline Assessment Scores by Participant	11; 6; 4	—
SECONDARY Change in Perifollicular Scale Assessments of Hairline Change by Study Physician	13; 6; 13; 8; 1; 1	—

Summary

The purpose of this study is to determine if the Revian Red All LED cap shows potential to be an effective treatment for Central centrifugal cicatricial alopecia (CCCA) by recruiting hair follicles back to anagen growth or by improving inflammation. The primary outcome is to determine if hair loss regression is halted. Secondary outcomes include hair regrowth and alleviation of signs and symptoms of the disease. Participants will be asked to use the Revian Red All LED cap once daily for a 10-minute treatment regimen which is the current androgenetic alopecia recommendation.

Eligibility Criteria

Inclusion Criteria

Women who are between the age of eighteen years and sixty-five years
Biopsy-proven diagnosis of CCCA Stage II-IV.
Must be on stable treatment without changes (on doxycycline, topical steroids, minoxidil and/or post 8 rounds of intralesional steroids) for at least 3 months

Exclusion Criteria

Subjects with other forms of hair loss that is not CCCA
Prior treatment with light source for alopecia
Males are excluded from this study since the prevalence of CCCA in males is so significantly low that it is difficult to find cases in a clinical setting

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05759338). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.