N/A Completed N=48 Randomized Double-blind Treatment

Scavenging of Reactive Carbonyl Species by Dietary Flavonoids in Humans

Human Health · Reactive Carbonyl Species · Polyphenols

Source: ClinicalTrials.gov NCT05773794 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2025

Primary outcomePrimary: Change in Urinary Levels of Reactive Carbonyl Species (RCS) of Soymilk, Green Tea, or Blueberry Over 8 Hours After One Single Dose of Soymilk, Green Tea, or Blueberry Consumption. — 3.71; 4.70; 5.01; 4.98 nmol/mSmo — p=0.968

Summary

This is an interventional study to investigate the formation and pharmacokinetics of reactive carbonyl species adducts of dietary polyphenols (soymilk, green tea, and blueberry) in humans after a single dose of dietary flavonoids.

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Urinary Levels of Reactive Carbonyl Species (RCS) of Soymilk, Green Tea, or Blueberry Over 8 Hours After One Single Dose of Soymilk, Green Tea, or Blueberry Consumption.	3.71; 4.70; 5.01; 4.98; 7.38; 8.10	0.968
PRIMARY Change in Plasma Levels of Reactive Carbonyl Species (RCS) of Soymilk, Green Tea, or Blueberry Over 4 Hours After One Single Dose of Soymilk, Green Tea, or Blueberry Consumption.	388.81; 414.10; 265.62; 266.84; 800.22; 783.50	0.016 sig
PRIMARY Change in Urinary Levels of Reactive Carbonyl Species (RCS) Adducts of Soymilk, Green Tea, or Blueberry Polyphenols Over 24 Hours After One Single Dose of Soymilk, Green Tea, or Consumption.	NA; NA; 0.042; NA; NA; NA	0.0196 sig
SECONDARY Change in Levels of Reactive Carbonyl Species (RCS) Adducts of Soymilk, Green Tea, or Blueberry Polyphenols in Feces Over 48 Hours After One Single Dose of Soymilk, Green Tea, or Consumption.	NA; NA; NA; NA; NA; NA	—
SECONDARY Change in Plasma Levels of Reactive Carbonyl Species (RCS) Adducts of Soymilk, Green Tea, or Blueberry Polyphenols Over 24 Hours After One Single Dose of Soymilk, Green Tea, or Consumption.	NA; NA; NA; NA; NA; NA	—

Eligibility Criteria

Inclusion Criteria

Age 25-70 years
BMI between 18 and 30
Have no known allergy to soy milk
Be not taking antibiotics for six months
Be not currently taking medication
No taking any prescription drugs
If supplements were taken, flavonoid-enriched supplements (see list below) should be avoided.

Major brands Notes: All flavonoid-enriched supplements should be avoided. Soy Isoflavones/ tea/blueberry Lipo-Flavonoid Citrus Bioflavonoids Complex Super Flavonoids Super Antioxidants Quercetin Supplement Essential-C and flavonoids Milk Thistle Other flavonoids supplements, including but not limited: Luteolin, Rutin, etc

No any drugs or supplements within three weeks of the experiment
Be nonsmoking
Have no alcoholic intoxication
No alcoholic addiction
2 years could be considered;

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05773794). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.