N/A
N=175
Safety and Effectiveness of Restylane Lyft With Lidocaine for Augmentation of the Chin Region to Improve the Chin Profile
Chin Augmentation · Chin Retrusion
Bottom Line
View on ClinicalTrials.gov: NCT05777759 ↗Enrolled (actual)
175
Serious AEs
1.2%
Results posted
May 2026
Primary outcome: Primary: Change From Baseline in the Blinded Evaluators' Live Assessment Using the Galderma Chin Retrusion Scale (GCRS) at Month 3 — -0.94; -1.02 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Restylane Lyft with Lidocaine (Device); Juvederm Voluma XC (Device)
- Age
- Adult, Older Adult · 22+ yrs
- Sex
- All
- Sponsor
- Galderma R&D
- Primary completion
- Nov 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change From Baseline in the Blinded Evaluators' Live Assessment Using the Galderma Chin Retrusion Scale (GCRS) at Month 3 |
-0.94; -1.02 | — |
| SECONDARY Responder Rate Based on the Blinded Evaluator's Live Assessment Using the GCRS at Months 6, 9, and 12 |
75.5; 80.0; 69.1; 79.2; 69.7; 77.8 | — |
Summary
The primary objective of the study was to demonstrate non-inferiority of Restylane Lyft with Lidocaine versus a comparator-control for augmentation of the chin region to improve the chin profile.
Eligibility Criteria
Inclusion Criteria
- Males or non-pregnant, non-breastfeeding females, 22 years of age or older
- Intent to receive treatment for augmentation and correction of retrusion in the chin region.
Exclusion Criteria
- Known/previous allergy of hypersensitivity to any injectable hyaluronic acid (HA) gel or gram-positive bacterial proteins.
- Known/previous allergy or hypersensitivity to local anesthetics, e.g., lidocaine or other amide-type anesthetics.
- Previous or present multiple severe allergies or severe allergies, such as manifested by anaphylaxis or angioedema or family history of angioedema.
- Previous facial surgery (including facial aesthetic surgery and liposuction), below the level of the horizontal line from the subnasale.
- Any previous aesthetic procedures or implants
- Presence of any disease or lesion near or on the area to be treated.
Data sourced from ClinicalTrials.gov (NCT05777759). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.