N/A
N=817,337
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Propranolol/Carvedilol Versus Atenolol/Bisoprolol/Sotalol
Hypertension
Bottom Line
View on ClinicalTrials.gov: NCT05794997 ↗Enrolled (actual)
817,337
Serious AEs
—
Results posted
Nov 2025
Primary outcome: Primary: Time to Dementia Onset — 22.96; 19.84; 26.82; 25.84 Incidence rate per 1000 person year
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- Propranolol or Carvedilol (Drug); Atenolol, Bisoprolol or Sotalol (Drug)
- Age
- Older Adult · 65+ yrs
- Sex
- All
- Sponsor
- Brigham and Women's Hospital
- Primary completion
- Jan 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Time to Dementia Onset |
22.96; 19.84; 26.82; 25.84; 23.03; 20.21 | — |
Summary
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the same indication.
Eligibility Criteria
Please see https://docs.google.com/spreadsheets/d/1ltZHHv6AvMkPBbSp\_9c0dtQ0XMmBc00d4jaRId5ovaA/edit?usp=sharing or Appendix A (https://drive.google.com/drive/folders/1a-1uRt73kVywEoV8L0cEmDNgaqYEIudT?usp=sharing) for full code and algorithm definitions.
Medicare timeframe: 2008 to 2019 (end of data availability).
Inclusion Criteria
- 1. Aged >/= 65 years on the index date
- 2. Enrollment in Medicare Part A, B, and D with no HMO coverage for 365 days prior to and including cohort entry date
- 3. At least 1 inpatient claim or 2 outpatient claims with hypertension diagnosis recorded in 365 days prior to drug initiation
Exclusion Criteria
- 1. Prior history of dementia measured anytime prior to cohort entry date
- 2. Prior history of nursing home admission in the 365 days prior to the cohort entry date
- 3. Prior use of Propranolol, Carvedilol and Atenolol, Bisoprolol, Sotalol
- 4. Use of Propranolol, Carvedilol and Atenolol, Bisoprolol, Sotalol concomitantly on index date
Data sourced from ClinicalTrials.gov (NCT05794997). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.