Phase 3
N=40
Efficacy of Eco-Friendly Toothpaste Tablets Versus Conventional Toothpaste Using PI and GI Index
Gingival Inflammation
Bottom Line
View on ClinicalTrials.gov: NCT05805865 ↗Enrolled (actual)
40
Serious AEs
0.0%
Results posted
Feb 2025
Primary outcome: Primary: Plaque Index Score at Baseline — 2.80; 2.78 Score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 3
- Interventions
- Toothpaste Tablet (Drug); Conventional Toothpaste (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Loma Linda University
- Primary completion
- Jan 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Plaque Index Score at Baseline |
2.80; 2.78 | — |
| PRIMARY Gingival Index Score at Baseline |
1.35; 1.37 | — |
| SECONDARY Subject Perception of Product Use |
2.0; 1.7 | — |
Summary
Objectives: To assess the change in gingival index (GI) and plaque index (PI) when comparing the use of toothpaste tablets to conventional toothpaste.
Methods: 40 participants were randomized into two groups: Colgate's toothpaste tablets (T) and Colgate's Cavity Protection toothpaste (C). Both groups utilized their assigned dentifrice for 2 weeks. A pre and post-assessment measured the GI and PI index. A questionnaire on the use of the product was distributed.
Eligibility Criteria
Inclusion Criteria
- Subjects are 18 years or older;
- Subjects who will comply with study protocol;
- Subjects who can read and understand the consent form;
- Subjects available during the study period;
- Subjects have more than 20 teeth.
Exclusion Criteria
- Subjects who are pregnant and/or nursing;
- Subjects under the age of 18.
Data sourced from ClinicalTrials.gov (NCT05805865). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.