Phase 1
Completed N=12
A Study to Learn About How Itraconazole Affects the Blood Level of Study Medicine (PF-07817883) in Healthy Adults.
Healthy
Source: ClinicalTrials.gov NCT05822440 ↗
Enrolled (actual)
12
Serious AEs
0.0%
Results posted
Oct 2024
Primary outcomePrimary: Maximum Observed Concentration (Cmax) of PF-07817883 — 4030; 4985 ng/mL
Summary
The purpose of this study is to learn how Itraconazole affects the blood level of PF-07817883 in Healthy Adults.
This study is seeking participants who are:
* male and female aged 18 to 65 years old,
* overtly healthy. This can be determined my medical evaluation, medical history, lab tests etc.
This study will consist of 2 parts, Period 1 and Period 2.
Period 1: participants will take PF-07817883 one time by mouth at the study clinic.
Period 2: participants will take PF-07817883 one time by mouth at the study clinic. They will also take daily itraconazole by mouth for 7 days.
Participants will stay at the study clinic for 2 weeks in total. The study doctors will collect blood and urine samples from everyone. The study doctors will check participants' reactions to the study medicine for safety measures. There is a follow-up call at 28 to 35 days from the last dose of PF-07817883.
Itraconazole is an approved medicine. It is also a metabolism inhibitor. When taken with some medicines, it affects the actual level of these medicines in the body. This study will compare blood levels of PF-07817883 given with and without Itraconazole. This will help decide safety and right amount for PF-07817883 when given with metabolism inhibitors.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Maximum Observed Concentration (Cmax) of PF-07817883 |
4030; 4985 | — |
| PRIMARY Area Under the Concentration -Time Curve From Time Zero (0) Extrapolated to Infinite Time (AUCinf) of PF-07817883 |
21720; 46400 | — |
| SECONDARY Number of Participants With Treatment Emergent Adverse Events (TEAEs) |
1; 3; 2 | — |
| SECONDARY Number of Participants With Laboratory Test Abnormalities |
0; 3 | — |
| SECONDARY Number of Participants With Electrocardiogram (ECG) Findings Per Pre-defined Criteria |
0; 1 | — |
| SECONDARY Number of Participants With Vital Signs Findings Per Pre-defined Criteria |
0; 1 | — |
| SECONDARY Number of Participants With Clinically Significant Abnormalities in Physical Examination |
0; 0 | — |
| SECONDARY Time to Reach Cmax (Tmax) of PF-07817883 |
1.76; 2.00 | — |
| SECONDARY Terminal Phase Half-Life (t1/2) of PF-07817883 |
5.502; 10.92 | — |
| SECONDARY Apparent Clearance (CL/F) of PF-07817883 |
13.81; 6.469 | — |
| SECONDARY Apparent Volume of Distribution (Vz/F) of PF-07817883 |
100.4; 86.29 | — |
Eligibility Criteria
Inclusion Criteria
- Male and female participants aged 18 to 65 years of age, inclusive, at screening who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and standard 12-lead ECG.
- BMI of 17.5 to 32 kg/m2; and a total body weight >50 kg (110 lb).
- Capable of giving signed informed consent.
Exclusion Criteria
- Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality or other conditions that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study.
- Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, CV, hepatic, psychiatric, neurological, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at the time of dosing) and, in the judgment of the investigator, would make the participant inappropriate for entry into this study.
- Any condition possibly affecting drug absorption (eg, gastrectomy, cholecystectomy).
- Positive test result for SARS-CoV-2 infection at admission.
Data sourced from ClinicalTrials.gov (NCT05822440). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.