Phase 4
Completed N=80
Effects of Adrenaline Infiltration on Surgical Field of View in Endoscopic Sinus Surgery
Intraoperative Bleeding
Source: ClinicalTrials.gov NCT05867342 ↗
Enrolled (actual)
80
Serious AEs
0.0%
Results posted
Jul 2023
Primary outcomePrimary: Surgical Field Grading Score — 3.54; 3.23 score on a scale — p=0.77
◆ Published Evidence
Emerging
15citations · ~3 / year
The effect of topical epinephrine 1:1000 with and without infiltration of 1% lidocaine with epinephrine 1:100,000 on endoscopic surgical field visualization: a double-blind randomized controlled study.
Summary
In endoscopic sinus surgery a clear surgical field of view is a very important aspect for good surgical outcome. This study is to evaluate the preoperative preparation to acquire best surgical field of view by comparing between the use of topical adrenaline and the use of combination of topical adrenaline with infiltration of 1% lidocaine with adrenaline in patients scheduled for endoscopic sinus surgery for rhinosinusitis.
Linked Publications
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The effect of topical epinephrine 1:1000 with and without infiltration of 1% lidocaine with epinephrine 1:100,000 on endoscopic surgical field visualization: a double-blind randomized controlled study.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Surgical Field Grading Score |
3.54; 3.23 | 0.77 |
| SECONDARY Duration of Surgery |
72.05; 54.23 | 0.002 sig |
| SECONDARY Number of Extra Pledgets Used |
3.25; 2.63 | 0.126 |
| SECONDARY Estimated Blood Loss During Surgery |
95.25; 91.63 | — |
| SECONDARY Postoperative Bloody Discharge Grading Score |
2.38; 2.2 | 0.213 |
| SECONDARY Number of Days With Postoperative Bloody Nasal Discharge |
2.85; 2.73 | 0.418 |
| SECONDARY Number of Nostrils With Continuous Fresh Bleeding |
7; 5 | 0.756 |
Eligibility Criteria
Inclusion Criteria
- Diagnosed with recurrent acute or chronic rhinosinusitis recalcitrant to medical treatment and scheduled for endoscopic sinus surgery
Exclusion Criteria
- Patients who have asymetrical disease on the two sides (Lund Mackay score difference more than 2)
- Patients who have endoscopic sinus surgery for treatment of tumor or disease other than sinusitis
- Patients with underlying uncontrolled hypertension
- Patients with bleeding disorder or are unable to discontinue antiplatelet or anticoagulant before the surgery
- Patients who are allergic to adrenaline or to xylocaine
Data sourced from ClinicalTrials.gov (NCT05867342) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.