N/A
N=100
High Protein, Core Muscle Rehab, Muscular Electrostimulation in Prolonged Mechanical Ventilation
Prolonged Mechanical Ventilation · Protein Deficiency
Bottom Line
View on ClinicalTrials.gov: NCT05932134 ↗Enrolled (actual)
100
Serious AEs
0.0%
Results posted
Dec 2025
Primary outcome: Primary: Weaning Rate — 3; 20; 22; 26 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- UC + high protein diet (HP) (Dietary_supplement); UC + HP + core muscle rehabilitation (Behavioral); UC + HP + core muscle rehabilitation + neuromuscular electric stimulation (NMES) (Device)
- Age
- Adult, Older Adult · 20+ yrs
- Sex
- All
- Sponsor
- Chang Gung Memorial Hospital
- Primary completion
- Mar 2025
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Weaning Rate |
3; 20; 22; 26 | — |
| SECONDARY In Hospital Mortality |
3; 5; 5; 4 | — |
| SECONDARY Length of Mechanical Ventilator Usage |
74.4; 56.5; 57.1; 41.1 | — |
| SECONDARY Length of ICU Stay |
31.3; 25.7; 26.0; 23.7 | — |
Summary
The goal of this clinical trial is to learn about in patients with prolong mechanical ventilation. This main questions aims to answer are:
* High protein formula intake benefit in successful weaning from ventilator
* Core muscle rehabilitation benefit in successful weaning from ventilator
* neuromuscular electric stimulation benefit in successful weaning from ventilator
Participants will receive high protein diet, core muscle rehabilitation, neuromuscular electric stimulation (NMES).
Researchers will compare patients with interventions to control group to see if high protein diet, core muscle rehabilitation, neuromuscular electric stimulation works.
Eligibility Criteria
Inclusion Criteria
- age ≥ 20 year old
- using mechanical ventilator for more than 21 days (including patients under tracheostomy or endotracheal tube)
- stable clinical condition, without using inotropic agent (arterial blood gas pH : 7.35-7.45, PaO2≥60 mm Hg at FiO2 40%, absence of signs and symptoms of uncontrolled infection, and hemodynamic stability)
- maximal inspiratory pressure (MIP) 35 kg/M2, or severe edema
- Patients with hepatic failure, rapid progressed malignancy, or pregnancy were also excluded.
- Under parenteral nutrition (PN)
- Use pacemaker
Data sourced from ClinicalTrials.gov (NCT05932134). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.