N/A
Completed N=31
Effect of Different E-cigarette Cooling Flavors on Adults' Sensory Experience TCORS 3.0
E-Cig Use
Source: ClinicalTrials.gov NCT05932693 ↗
Enrolled (actual)
31
Serious AEs
0.0%
Results posted
Jan 2026
Primary outcomePrimary: Coolness: Score Change in Coolness of Each E-cigarette Condition (16 Conditions in Total) — 2.70; 3.35; 5.43; 8.13 Scores on a scale
Summary
This pilot sensory experiment will examine cooling from comparable concentrations of WS-3 and menthol to determine appropriate concentrations to use in the main study.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Coolness: Score Change in Coolness of Each E-cigarette Condition (16 Conditions in Total) |
2.70; 3.35; 5.43; 8.13; 11.61; 3.91 | — |
Eligibility Criteria
Inclusion Criteria
- 18 years or older
- Able to read and write
- Used e-cigarettes containing nicotine
- Use e-cigs in past 30 days
- No strong dislike of the menthol flavor
- Urine cotinine ≥200ng/ml
- Willing to abstain from tobacco/nicotine use 2 hrs prior to sessions
Exclusion Criteria
- Known hypersensitivity to propylene glycol
- Pregnant or lactating females
- Uncontrolled asthma
- Nut/e-liquid flavorant allergy
- Current marijuana (tetrahydrocannabinol) vaping + E-cigarette or vaping use Associated Lung Injury (EVALI) symptoms
- Dislike of menthol flavor
Data sourced from ClinicalTrials.gov (NCT05932693). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.