Mode
Text Size
Log in / Sign up
N/A N=76 Randomized Single-blind Prevention

Intergenerational Behavioral Intervention to Enhance Physical Activity in Older Adults at Risk for Alzheimer's Disease

Physical Inactivity

Enrolled (actual)
76
Serious AEs
0.0%
Results posted
Jul 2025
Primary outcome: Primary: Total Step Count (Average Steps/Day) — 5648.91; 3809.62 Steps/day — p=<0.001

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Motivational behavioural intervention and daily activities monitoring (Behavioral); Active Control (Behavioral)
Age
Adult, Older Adult · 60+ yrs
Sex
All
Sponsor
Douglas Mental Health University Institute
Primary completion
Apr 2024

Outcome Measures

OutcomeResultp-value
PRIMARY
Total Step Count (Average Steps/Day)
5648.91; 3809.62 <0.001 sig
SECONDARY
The Modified Differential Emotions Scale (mDES) Negative Emotions
1.18; 1.31
SECONDARY
Generativity - Achievement
25.09; 22.58
SECONDARY
Test My Brain Digital Neuropsychology Toolkit - Backwards Digit Span
6.58; 4.89 <0.01 sig
SECONDARY
Loneliness
53.71; 44.87
SECONDARY
Modified Differential Emotions Scale (mDES) Positive Emotions
3.38; 3.40
SECONDARY
Generativity Desire
31.67; 29.72
SECONDARY
Test My Brain Digital Neuropsychology Toolkit - Choice Reaction Time
1293.08; 1136.67
SECONDARY
Test My Brain Digital Neuropsychology Toolkit - Digit Symbol Matching
38.81; 36.83
SECONDARY
Test My Brain Digital Neuropsychology Toolkit - Forward Digit Span
6.91; 6.18
SECONDARY
Test My Brain Digital Neuropsychology Toolkit - Gradual Onset Continuous Performance C
0.45; 0.40
SECONDARY
Test My Brain Digital Neuropsychology Toolkit - Gradual Onset Continuous Performance D
2.80; 2.87
SECONDARY
Test My Brain Digital Neuropsychology Toolkit - Matrix Reasoning
22.18; 22.58
SECONDARY
Test My Brain Digital Neuropsychology Toolkit - Serial Reaction Time
333.24; 384.62
SECONDARY
Test My Brain Digital Neuropsychology Toolkit - Visual Paired Associates
16.2; 16.3

Summary

This is a four-week pilot randomized controlled trial of a behavioral intervention in older adults at risk for Alzheimer's disease. Older participants are a subgroup from the PREVENT-AD longitudinal cohort. We will test whether a four-week intergenerational social motivation using a technology-based platform (intervention group) enhances physical activity relative to a control group.

Eligibility Criteria

Main Participant Inclusion criteria:

Men and women > 60 years Who are current participants of the PREVENT-AD Longitudinal Cohort at McGill University.

No contraindications to MRI Imaging. Normal cognition Not exercising more than 150 minutes of moderate-intensity exercise per week or sitting more than 8 hours per day AND responded "yes" to the question "Do you want to increase your physical activity?" Fluency in English or French Access to a computer or smartphone with internet Normal or corrected-to-normal vision based on the minimal 20/20 standard Ambulatory without significant increase in pain with walking or the assistance of walking devices

Main Participant Exclusion Criteria:

Primary care physician does not approve additional physical activity An inability to ambulate without the assistance of another person or severe pain

Any unstable medical condition:

  • History of a psychiatric illness including schizophrenia or Attention Deficit Hyperactivity Disorder (ADHD). History of anxiety or depression accepted if stable on medication for at least 6 months
  • Current treatment for cancer - except non-melanoma skin cancer
  • Neurological condition (e.g., multiple sclerosis, Parkinson's disease, and stroke)
  • Current alcohol or substance abuse
  • Current treatment for congestive heart failure, angina, uncontrolled arrhythmia, Deep Venous Thrombosis (DVT) or other unstable cardiovascular condition
  • Myocardial infarction, coronary artery bypass grafting, angioplasty or other cardiac event in the past six months.

Younger Adult Inclusion Criteria:

  • Can be identified as child or grandchild of participant (biological or adopted), 14 years or older.
  • Can be a young adult (18 years or older) who is not a relative of the main participant, in case a grandchild or child is not available.
  • Stable on antidepressants for more than 6 months.
  • In contact with the primary participant more than once per 12 months at baseline
  • Lives anywhere in Canada if 18 years and older, or anywhere accessible by mail in Quebec if 14 years and older but younger than 18 years.
  • Normal or corrected-to-normal vision based on the minimal 20/20 standard to complete the cognitive tasks
  • Able to speak, read, and write English or French
  • No diagnosis of neurological disease or unstable health condition

Study Partner Exclusion Criteria:

  • Not in contact with the primary participant more than once per 12 months at baseline
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT06038643). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

Back to search