Intergenerational Behavioral Intervention to Enhance Physical Activity in Older Adults at Risk for Alzheimer's Disease
Physical Inactivity
Bottom Line
View on ClinicalTrials.gov: NCT06038643 ↗Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Motivational behavioural intervention and daily activities monitoring (Behavioral); Active Control (Behavioral)
- Age
- Adult, Older Adult · 60+ yrs
- Sex
- All
- Sponsor
- Douglas Mental Health University Institute
- Primary completion
- Apr 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Total Step Count (Average Steps/Day) |
5648.91; 3809.62 | <0.001 sig |
| SECONDARY The Modified Differential Emotions Scale (mDES) Negative Emotions |
1.18; 1.31 | — |
| SECONDARY Generativity - Achievement |
25.09; 22.58 | — |
| SECONDARY Test My Brain Digital Neuropsychology Toolkit - Backwards Digit Span |
6.58; 4.89 | <0.01 sig |
| SECONDARY Loneliness |
53.71; 44.87 | — |
| SECONDARY Modified Differential Emotions Scale (mDES) Positive Emotions |
3.38; 3.40 | — |
| SECONDARY Generativity Desire |
31.67; 29.72 | — |
| SECONDARY Test My Brain Digital Neuropsychology Toolkit - Choice Reaction Time |
1293.08; 1136.67 | — |
| SECONDARY Test My Brain Digital Neuropsychology Toolkit - Digit Symbol Matching |
38.81; 36.83 | — |
| SECONDARY Test My Brain Digital Neuropsychology Toolkit - Forward Digit Span |
6.91; 6.18 | — |
| SECONDARY Test My Brain Digital Neuropsychology Toolkit - Gradual Onset Continuous Performance C |
0.45; 0.40 | — |
| SECONDARY Test My Brain Digital Neuropsychology Toolkit - Gradual Onset Continuous Performance D |
2.80; 2.87 | — |
| SECONDARY Test My Brain Digital Neuropsychology Toolkit - Matrix Reasoning |
22.18; 22.58 | — |
| SECONDARY Test My Brain Digital Neuropsychology Toolkit - Serial Reaction Time |
333.24; 384.62 | — |
| SECONDARY Test My Brain Digital Neuropsychology Toolkit - Visual Paired Associates |
16.2; 16.3 | — |
Summary
Eligibility Criteria
Main Participant Inclusion criteria:
Men and women > 60 years Who are current participants of the PREVENT-AD Longitudinal Cohort at McGill University.
No contraindications to MRI Imaging. Normal cognition Not exercising more than 150 minutes of moderate-intensity exercise per week or sitting more than 8 hours per day AND responded "yes" to the question "Do you want to increase your physical activity?" Fluency in English or French Access to a computer or smartphone with internet Normal or corrected-to-normal vision based on the minimal 20/20 standard Ambulatory without significant increase in pain with walking or the assistance of walking devices
Main Participant Exclusion Criteria:
Primary care physician does not approve additional physical activity An inability to ambulate without the assistance of another person or severe pain
Any unstable medical condition:
- History of a psychiatric illness including schizophrenia or Attention Deficit Hyperactivity Disorder (ADHD). History of anxiety or depression accepted if stable on medication for at least 6 months
- Current treatment for cancer - except non-melanoma skin cancer
- Neurological condition (e.g., multiple sclerosis, Parkinson's disease, and stroke)
- Current alcohol or substance abuse
- Current treatment for congestive heart failure, angina, uncontrolled arrhythmia, Deep Venous Thrombosis (DVT) or other unstable cardiovascular condition
- Myocardial infarction, coronary artery bypass grafting, angioplasty or other cardiac event in the past six months.
Younger Adult Inclusion Criteria:
- Can be identified as child or grandchild of participant (biological or adopted), 14 years or older.
- Can be a young adult (18 years or older) who is not a relative of the main participant, in case a grandchild or child is not available.
- Stable on antidepressants for more than 6 months.
- In contact with the primary participant more than once per 12 months at baseline
- Lives anywhere in Canada if 18 years and older, or anywhere accessible by mail in Quebec if 14 years and older but younger than 18 years.
- Normal or corrected-to-normal vision based on the minimal 20/20 standard to complete the cognitive tasks
- Able to speak, read, and write English or French
- No diagnosis of neurological disease or unstable health condition
Study Partner Exclusion Criteria:
- Not in contact with the primary participant more than once per 12 months at baseline
Data sourced from ClinicalTrials.gov (NCT06038643). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.