N/A
N=100
The Efficacy of Adjuvant Oral Care in Prevention of Ventilator Associated Pneumonia.
Pneumonia, Ventilator-Associated
Bottom Line
View on ClinicalTrials.gov: NCT06039995 ↗Enrolled (actual)
100
Serious AEs
0.0%
Results posted
Jan 2026
Primary outcome: Primary: Incidence of Ventilator-Associated Pneumonia (VAP) — 16; 27 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Comprehensive Oral Care (Procedure); Traditional Oral Care (Procedure); Mechanical Tooth Brushing using 0.2% Chlorhexidine (Device); Moisturizing Gel (Device); Oral care using Cotton swab dipped in 0.2% Chlorhexidine (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Health Sciences Lahore
- Primary completion
- Jan 2025
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Incidence of Ventilator-Associated Pneumonia (VAP) |
16; 27 | — |
| SECONDARY Duration of ICU Stay |
12.28; 11.19 | — |
| SECONDARY Mortality Rates |
22; 33 | — |
Summary
A Randomized Controlled Trial (RCT) at Services Hospital, Lahore, aims to reduce Ventilator-Associated Pneumonia (VAP) incidence and mortality rates while shortening ICU stays in mechanically ventilated patients by adding adjuvant oral care to traditional practices.
Study Objectives:
Focus: ICU patients on mechanical ventilation. Question: Does adjuvant oral care reduce VAP rates and ICU stays?
Methodology:
Sample: Minimum 100 eligible subjects via convenient sampling. Randomization: Computer software for unbiased group allocation. Interventions: Intervention group gets Chlorhexidine mouthwash, toothbrushing, and oral gel; control group gets 0.2% Chlorhexidine mouthwash.
Measures: Evaluate VAP using Modified Clinical Pulmonary Infection Score (MCPIS) and compare demographic data.
Statistical Analysis: SPSS v22 to analyze data.
Expected Impact:
Potential to reduce VAP and improve ICU patient outcomes. Cost-effective treatment with adjuvant oral care. Shorter ICU stays, relieving VAP burden. Enhanced patient care, reduced mortality, and resource strain. Aligns with reducing VAP incidence and improving ICU patient care.
Eligibility Criteria
Inclusion Criteria
- ICU patients on intensive mechanical ventilation aged 18-65 years of either sex with oral ETT in situ.
- MCPIS score between 0 to 5 on first day of admission at ICU
Exclusion Criteria
- More than 48 hours of mechanical ventilation before ICU admission.
- Previous history of respiratory illness.
- Immunocompromised.
- Ongoing sepsis.
- Pregnancy.
- Presence of dentures.
Data sourced from ClinicalTrials.gov (NCT06039995). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.