N/A Completed N=919 Randomized Single-blind Health Services Research

PROmotion of COVID-19 BOOSTer VA(X)Ccination in the Emergency Department - PROBOOSTVAXED

COVID

Source: ClinicalTrials.gov NCT06156215 ↗

Enrolled (actual)

919

Serious AEs

0.0%

Results posted

Sep 2025

Primary outcomePrimary: Number of Participants With 30-day Booster Vaccine Uptake — 14; 10 Participants

Summary

The goal of this cluster randomized clinical trial is to test the efficacy of messaging interventions to increase booster vaccine uptake in adults in the emergency department(ED). The main question[s] and goals of this study are: * does the intervention of vaccine messaging increase booster vaccine uptake at 30 days post ED visit? * does the intervention of asking about vaccine acceptance increase booster vaccine uptake at 30 days post ED visit? * considering recent national changes to funding and availability of updated vaccines, the investigators will examine the effects of these changes on vaccine acceptance and uptake in ED populations. Specifically, they will stratify EDs and ED patients according to the ED availability of vaccines, and they will also examine whether costs and availability of vaccines are a deterrent to patient acceptance and uptake of vaccines

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Participants With 30-day Booster Vaccine Uptake	14; 10	—
SECONDARY Number or Participants Receiving Booster Vaccination in the ED	8; 7; 0	—
SECONDARY Number of Participants Stating They Would Accept Vaccine in the ED	73; 90	—
SECONDARY Number of Participants With 30-day Booster Vaccine Uptake, Q Arm	11; 10	—

Eligibility Criteria

Inclusion Criteria

Age > 18 years
Presenting to ED
No receipt of COVID-19 booster within prior 6 months
Able to provide informed consent
Fluent in English or Spanish
Anticipated ability to complete study intervention in ED i.e., able to watch a 3-minute videoclip

Exclusion Criteria

Major trauma such that it will preclude survey
Inability to participate in a survey because of intoxication, altered mental status, or critical illness
Incarceration
Psychiatric hold
Patients who state that they have already received a bivalent COVID-19 booster vaccine or other COVID-19 vaccine within the prior 6 months
Patients who are in the ED for suspected acute COVID-19

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT06156215). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.