N/A
N=70
Effect of Irrigation-Activation Techniques on Healing in Large Periapical Lesions
Effect of Irrigation Activation on Periapical Healing
Bottom Line
View on ClinicalTrials.gov: NCT06204887 ↗Enrolled (actual)
70
Serious AEs
—
Results posted
May 2025
Primary outcome: Primary: Percentage Change in Lesion Volume at 12-months Follow-up — 80.429; 85.429; 86.929; 74.571 percent change — p=<0.05
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Manual dynamic activation (Procedure); Passive ultrasonic activation (Procedure); Laser activation (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Recep Tayyip Erdogan University
- Primary completion
- Feb 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percentage Change in Lesion Volume at 12-months Follow-up |
80.429; 85.429; 86.929; 74.571 | <0.05 sig |
| PRIMARY Distribution of Lesion Status in Different Irrigation Groups at 12-year Follow-up |
3; 1; 4; 3; 9; 13 | — |
Summary
The aim of this study was to highlight the healing rates of large periapical lesions after different irrigation activation treatments as manual dynamic activation (MDA), passive ultrasonic irrigation (PUI), shock wave-enhanced emission photoacoustic streaming (SWEEPS) using CBCT scans based on volumetric change analysis during 1-year follow-up.
Eligibility Criteria
Inclusion Criteria
- Patients having single root mandibular teeth
- Patients the diagnosis of chronic apical periodontitis,
- Periapical index score of 3 and above,
- Patients having good oral hygiene
Exclusion Criteria
- Patients with systemic diseases (diabetes, hypertension, chronic liver disease, coagulation disorders),
- Patients with bone metabolism disease and/or
- Patients using drugs that affect bone metabolism (such as steroids, bisphosphonates)
- Patients with a history of radiotherapy
- Pregnant patients
- Teeth with mobility of 2 or more, periodontal pocket depth of 5 mm or more, generalized chronic periodontitis, internal and external resorption, and/or vertical and horizontal root fractures
Data sourced from ClinicalTrials.gov (NCT06204887). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.