N/A Completed N=70 Randomized Single-blind Treatment

Effect of Irrigation-Activation Techniques on Healing in Large Periapical Lesions

Effect of Irrigation Activation on Periapical Healing

Source: ClinicalTrials.gov NCT06204887 ↗

Enrolled (actual)

Serious AEs

—

Results posted

May 2025

Primary outcomePrimary: Percentage Change in Lesion Volume at 12-months Follow-up — 80.429; 85.429; 86.929; 74.571 percent change — p=<0.05

Summary

The aim of this study was to highlight the healing rates of large periapical lesions after different irrigation activation treatments as manual dynamic activation (MDA), passive ultrasonic irrigation (PUI), shock wave-enhanced emission photoacoustic streaming (SWEEPS) using CBCT scans based on volumetric change analysis during 1-year follow-up.

Outcome Measures

Outcome	Result	p-value
PRIMARY Percentage Change in Lesion Volume at 12-months Follow-up	80.429; 85.429; 86.929; 74.571	<0.05 sig
PRIMARY Distribution of Lesion Status in Different Irrigation Groups at 12-year Follow-up	3; 1; 4; 3; 9; 13	—

Eligibility Criteria

Inclusion Criteria

Patients having single root mandibular teeth
Patients the diagnosis of chronic apical periodontitis,
Periapical index score of 3 and above,
Patients having good oral hygiene

Exclusion Criteria

Patients with systemic diseases (diabetes, hypertension, chronic liver disease, coagulation disorders),
Patients with bone metabolism disease and/or
Patients using drugs that affect bone metabolism (such as steroids, bisphosphonates)
Patients with a history of radiotherapy
Pregnant patients
Teeth with mobility of 2 or more, periodontal pocket depth of 5 mm or more, generalized chronic periodontitis, internal and external resorption, and/or vertical and horizontal root fractures

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Data sourced from ClinicalTrials.gov (NCT06204887). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.