N/A
N=75
Investigation of the Effects of H-PRF on the Period After Impacted Third Molar Tooth Extraction
Impacted Third Molar Tooth
Bottom Line
View on ClinicalTrials.gov: NCT06244797 ↗Enrolled (actual)
75
Serious AEs
0.0%
Results posted
Jan 2026
Primary outcome: Primary: Postoperative Facial Swelling (Sum of 3 Linear Distances, mm) — 122.08; 118.55; 116.90; 119.68 Millimeters (mm)
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- L-PRF and H-PRF (Procedure); Impacted Tooth Removal (Procedure)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- esengul sen
- Primary completion
- Mar 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Postoperative Facial Swelling (Sum of 3 Linear Distances, mm) |
122.08; 118.55; 116.90; 119.68; 115.69; 114.23 | — |
| PRIMARY Maximum Interincisal Distance (Mouth Opening, mm) |
28.56; 29.48; 31.20; 38.96; 39.48; 38.92 | — |
| SECONDARY Soft Tissue Healing (Landry Index, 5-point Scale) |
8; 3; 6; 14; 13; 9 | — |
| SECONDARY Postoperative Pain (Visual Analog Scale, 0-10) |
6; 5; 6; 5; 4; 4 | — |
| SECONDARY Oral Health-Related Quality of Life (Majid Questionnaire, Total Score 0-42) |
11.56; 10.67; 12.92 | — |
| SECONDARY Oral Health-Related Quality of Life (Majid Questionnaire Subscales; Days With Symptoms, 0-7) |
1; 2; 1; 1; 1.5; 2 | — |
| SECONDARY Oral Health-Related Quality of Life (Majid - Eating & Drinking; Days With Symptoms, 0-7) |
2.96; 3.17; 3.6 | — |
Summary
After wisdom teeth are extracted, the patient may have some complaints in the post-operative period. Pain, swelling and edema are some of them. These inflammatory complications are important for patients and surgeons to reduce the risk of complications and ensure postoperative recovery and develop customized strategy. Many studies have been conducted in the literature to minimize these situations encountered after tooth extraction.
Eligibility Criteria
Inclusion Criteria
- Volunteer ASA I individuals between the ages of 18-40
Exclusion Criteria
- Those who are pregnant or lactating
- Those receiving anticoagulant or antiplatelet drug therapy
- Those who received radiotherapy to the head and face area
- Those who are allergic to local anesthetics and prescribed medications
Data sourced from ClinicalTrials.gov (NCT06244797). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.