N/A
N=76
InformationSeekingMesolimbicEngagementStudy1
Motivation
Bottom Line
View on ClinicalTrials.gov: NCT06257446 ↗Enrolled (actual)
76
Serious AEs
0.0%
Results posted
Apr 2026
Primary outcome: Primary: Mesolimbic-hippocampal Interactions — .153; .150 standardized beta-value — p==.09
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Task Instructions (Behavioral)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Temple University
- Primary completion
- Feb 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mesolimbic-hippocampal Interactions |
.153; .150 | =.09 |
| PRIMARY Episodic Memory |
.75; .751 | =.20 |
Summary
Study 1 will use a novel Game Show task, in which the investigators manipulate participant's agency to control their learning environment to specify unguided exploration.
Eligibility Criteria
Inclusion Criteria
- 20/40 far acuity (either corrected or uncorrected)
- In good medical health
Exclusion Criteria
- History of head injury
- History of illness with Central Nervous Systems implications
- On Medications that Affect blood flow response and alertness
- Consumption of smoking and/or coffee 30 minutes prior to laboratory testing
- Placement of a device contraindicated for magnetic resonance imaging including cardia pacemaker, aneurysm clip, cochlear implants, pregnancy, intra-uterine device, shrapnel, metal fragments in the eyes, neurostimulators
- Weight > 250lbs
- Claustrophobia
Data sourced from ClinicalTrials.gov (NCT06257446). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.