N/A
Completed N=90
A Study of Ropivacaine Complex Methylene Blue Fascia Iliaca Compartment Block on Analgesia in Patients Undergoing Hip Arthroplasty
Femoral Neck Disease
Source: ClinicalTrials.gov NCT06284941 ↗
Enrolled (actual)
90
Serious AEs
0.0%
Results posted
Feb 2025
Primary outcomePrimary: Visual Analogue Scale（VAS） — 3.0; 4.0 score
Summary
Total hip arthroplasty is currently the most effective method for treating hip joint lesions and improving quality of life, but postoperative severe pain is not conducive to rapid recovery of patients. In recent years, the widespread application of ultrasound has achieved good clinical results in iliac fascia block for postoperative analgesia in THA. However, the use of high-dose local anesthetics can increase the risk of local anesthetic poisoning, and the single block analgesia time is generally less than 24 hours. Methylene blue, as a long-acting analgesic drug, can block the pain transmission of nerve fibers for a long time, achieving analgesic effects without damaging neurons. This study used ultrasound-guided ropivacaine combined with methylene blue to perform iliac fascia block on patients undergoing total hip replacement, with the aim of prolonging pain relief time, reducing complications, and promoting postoperative recovery on the basis of traditional methods.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Visual Analogue Scale（VAS） |
3.0; 4.0 | — |
| SECONDARY Hypersensitive C-reactive Protein |
— | — |
| SECONDARY Procalcitonin |
— | — |
| SECONDARY Neutrophil Lymphocyte Ratio |
— | — |
| SECONDARY Mean Arterial Pressure |
— | — |
| SECONDARY Heart Rate |
— | — |
| SECONDARY Duration of Surgery |
— | — |
| SECONDARY Number of Postoperative Salvage Analgesia |
— | — |
| SECONDARY Walking Distance for the First Time Getting Out of Bed |
— | — |
| SECONDARY The Number of Activities of Getting Out of Bed 48 Hours After Surgery |
— | — |
Eligibility Criteria
Inclusion Criteria
- Hip replacement surgery is indicated
- ASA Class II - Class III
- No history of analgesic or local anesthetic allergy
- No history of alcohol abuse or narcotic drug abuse
- Patients and their families have given informed consent and signed the informed consent form
Exclusion Criteria
- Patient or family refusal to participate in the study
- Severe coagulation abnormalities
- Local anesthetic allergy
- Severe psychiatric illness or other communication disorder
- There is an infection at the puncture site
- History of neurological disease such as Guillain-Barré syndrome
- Delay in awakening post-surgery for more than 60 min,
- Post-surgical use of an analgesic pump
- Inability to follow-up at the required time points.
Data sourced from ClinicalTrials.gov (NCT06284941). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.