N/A
Completed N=12
Interleukin-2 (IL-2), Interleukin-5 (IL-5) and Interleukin-17 (IL-17) Levels of Patients With Stainless Steel Crowns
Saliva · Dental Crown · Nickel Sensitivity
Source: ClinicalTrials.gov NCT06439095 ↗
Enrolled (actual)
12
Serious AEs
0.0%
Results posted
Jun 2025
Primary outcomePrimary: IL-2, IL-5, IL-17 Expression Level (Fold Change) — 1.2; 1.8; 4.5 Fold Change
Summary
The aim of this study is to investigate whether nickel hypersensitivity following stainless steel crown treatment in children aged 3-9 leads to an increase in IL-2, IL-5, and IL-17 levels by analyzing saliva samples. By doing so, the study seeks to prevent potential hypersensitivity reactions after stainless steel crown treatment.
The main question it aims to answer is:
Which interleukin level increases in the controls 1 week after stainless steel crowns are applied? Researchers will investigate whether there is a significant increase in interleukin levels in children's saliva before and after the procedure.
Participants will:
They will provide saliva samples before stainless steel crowns are applied They will visit the clinic after 1 week for check-ups and tests.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY IL-2, IL-5, IL-17 Expression Level (Fold Change) |
1.2; 1.8; 4.5 | — |
Eligibility Criteria
**Inclusion Criteria:**
- Patients with teeth requiring stainless steel crowns due to having caries on two or more surfaces.
- Pediatric patients between 3-9 years old
**Exclusion Criteria:**
- Patients having any dental materials, such as fillings, fissure sealants, root canal treatments, or space maintainers
- Patients with known allergies to various foods and materials.
- Patients with systemic diseases that affect the immune system.
- Patients with a history of chemotherapy or radiotherapy.
Data sourced from ClinicalTrials.gov (NCT06439095). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.