Phase 4
Completed N=150
The Role of Verapamil in Radial Artery Spasm
Radial Artery Spasm
Source: ClinicalTrials.gov NCT06447688 ↗
Enrolled (actual)
150
Serious AEs
0.0%
Results posted
Oct 2025
Primary outcomePrimary: Number of Participants With Clinical Radial Artery Spasm (RAS) — 23; 3 participants
◆ Published Evidence
Emerging
1citation · ~1 / year
The Role of Oral Verapamil in Preventing Radial Spasm During Transradial Angiography.
Summary
Coronary angiography (CAG) is an invasive imaging method performed to determine the degree of coronary artery disease. Radial artery spasm (RAS) is one of the most common complications during coronary angiography performed via the transradial approach, causing patient discomfort or sometimes interrupting the procedure. There are many studies on RAS, and various pharmacoagents administered intravenously (intraarterial) to prevent RAS have been described. However, there is limited data in the literature regarding oral pharmacoagents that will prevent this complication. In our study, the preventive effect of Verapamil, given orally 2 hours before coronary angiography, on radial artery spasm will be investigated.
Linked Publications
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The Role of Oral Verapamil in Preventing Radial Spasm During Transradial Angiography.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Clinical Radial Artery Spasm (RAS) |
23; 3 | — |
| PRIMARY Number of Participants With Ultrasonographically Confirmed Radial Artery Spasm (Ultrasonographic RAS) |
36; 8 | — |
| SECONDARY Number of Participants With Procedural Success |
75; 75 | — |
| SECONDARY Mean Volume of Contrast Media Used (mL) (mL) |
133.8; 136.4 | — |
| SECONDARY Mean of the Dose Area Product (DAP) |
873.9; 878.8 | — |
| SECONDARY Mean of the Fluoroscopy Time |
7.9; 6.9 | — |
Eligibility Criteria
Inclusion Criteria
- Patients who undergo daily coronary angiography
- Whose Allen test is normal.
- Must be able to swallow tablets
Exclusion Criteria
- Allen test results are distorted,
- No pulse in the radial artery,
- Patients who have previously undergone radial angiography and whose hemodynamics are compromised will be excluded from the study.
- Patients with known contraindications to verapamil (significant aortic stenosis, heart rate <50/min, high-grade atrioventricular block, myocardial infarction) complicated with cardiogenic shock, or left ventricular ejection fraction <35%).
Data sourced from ClinicalTrials.gov (NCT06447688) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.