N/A
N=96
Effect of a Sequence of Specific Manual Therapy Techniques Targeting the Autonomic Nervous System in Healthy Adults
Autonomic Imbalance
Bottom Line
View on ClinicalTrials.gov: NCT06477822 ↗Enrolled (actual)
96
Serious AEs
0.0%
Results posted
May 2026
Primary outcome: Primary: Change in Heart Rate — -2.40; -0.94 beat per minute
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Sequence of manual therapy techniques (Procedure); Simulated manual therapy techniques (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Universitat Internacional de Catalunya
- Primary completion
- Jan 2026
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Heart Rate |
-2.40; -0.94 | — |
| PRIMARY Change in Root Mean Square of the Successive Differences Between Adjacent RR Intervals (RMSSD) in Heart Rate Variability Index |
5.90; 1.38 | — |
| SECONDARY Change in High Frequency (HF) Band in Heart Rate Variability Index |
23343.08; 9522.77 | — |
| SECONDARY Change in Respiratory Rate |
-0.88; -0.27 | — |
Summary
The activity of the autonomic nervous system has been shown to influence the appearance of symptoms in some diseases such as rheumatoid arthritis, fibromyalgia, or migraine, among others. In the bibliography we find different authors who, through intervention using manual therapy, have demonstrated its effects on the autonomic nervous system, especially on the increase in parasympathetic activity and reduction in sympathetic activity. A clinical trial is proposed to verify these effects.
Eligibility Criteria
Inclusion Criteria
- Provision of informed consent
- Aged between 18-65
Exclusion Criteria
- Regular consumtion of alcohol or illegal drugs
- Consumption of medications whose effect acts on the autonomic nervous system (cholinergic agonists and antagonists, or adrenergic agonists and antagonists)
- Diagnostic of disease that may affect the activity of the autonomic nervous system or the perception of pain (such as generalized anxiety disorder, fibromyalgia, or chronic fatigue).
- Pregnancy
Data sourced from ClinicalTrials.gov (NCT06477822). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.