N/A
N=60
Mindfulness-Based Intervention for Stress Reduction in Adult Singaporeans a Pilot Study
Mindfulness Meditation
Bottom Line
View on ClinicalTrials.gov: NCT06765889 ↗Enrolled (actual)
60
Serious AEs
—
Results posted
Jul 2025
Primary outcome: Primary: Self-reported Stress — 1.89; 1.87; 1.59; 1.68 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Mindfulness intervention (Behavioral); Control condition (Behavioral)
- Age
- Adult, Older Adult · 21+ yrs
- Sex
- All
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
- Primary completion
- Apr 2025
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Self-reported Stress |
1.89; 1.87; 1.59; 1.68; 1.96; 1.89 | — |
| SECONDARY Physiological Stress |
— | — |
| SECONDARY Ecological Momentary Assessment - (EMA) |
— | — |
Summary
This pilot study investigates self-administered mindfulness (SAM) as a stress reduction intervention, serving as a feasibility assessment for a larger multi-site trial. The research addresses gaps in mindfulness literature, particularly timely given that stress profoundly affects individuals' lives, shaping their thoughts, behaviors, and emotional experiences (Aldwin, 2007; Lazarus & Folkman, 1984), and plays a significant role in conditions like depression and anxiety (Yang et al., 2015).
The study implements a sham meditation control condition, improving upon passive controls that often yield inflated effect sizes (Patterson et al., 2016). The methodology incorporates both subjective measures, addressing limitations noted by Nichols et al. (2008), and heart rate variability (HRV) measurements. HRV has proven useful for its sensitivity to stress-induced changes (Goldberger et al., 2001), with higher values indicating better parasympathetic recovery (Shaffer & Ginsberg, 2017; Michels et al., 2013).
Set in Singapore, where stress management is a significant concern (Chodavadia et al., 2023), the study builds on Kabat-Zinn's (2003, 2006) definition of mindfulness. Unlike traditional programs, these interventions are more accessible (Spijkerman et al., 2016).
Recent meta-analyses show mixed findings: some identified small but significant effects (Cavanagh et al., 2018; Taylor et al., 2021), while others found no evidence of effectiveness after accounting for publication bias (Sparacio et al., 2024a). The study considers Singapore's unique cultural position (Li, Ngin, & Teo, 2007) and utilizes smartphone-based HRV monitoring, supported by research validating PPG technology (Guede-Fernández et al., 2020).
Through its comprehensive approach and robust design, this pilot study aims to establish a foundation for future research while providing insights into SAM's effectiveness as a stress reduction technique.
Eligibility Criteria
Inclusion Criteria
- Be at least 21 years old.
- Possess a smartphone capable of running the study applications with internet access.
- Be fluent in the English language.
- Have sufficient vision and hearing to complete the study procedures.
Exclusion Criteria
- Engaged in meditation within the six months preceding the experiment.
- Member of the research team or an immediate family member (defined as spouses, parents, children, or siblings, whether biological or legally adopted).
- Currently taking psychoactive medications, including antidepressants, anxiolytics, hypnotics, or stimulants, or having used these medications in the past week.
- History of major neurological or psychiatric disease within the past six months.
Data sourced from ClinicalTrials.gov (NCT06765889). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.