N/A
N=100
Capillary Leak Index as a Prognostic Indicator for Post-Operative Abdominal Sepsis in Critically Ill Patients
Intra-Abdominal Infections · Intestinal Obstruction · Appendicitis Acute · Perforated Viscus
Bottom Line
View on ClinicalTrials.gov: NCT06901544 ↗Enrolled (actual)
100
Serious AEs
62.0%
Results posted
Dec 2025
Primary outcome: Primary: Number of Participants Who Died by Day 28 — 8; 23 Participants — p=0.001
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Ain Shams University
- Primary completion
- Aug 2025
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants Who Died by Day 28 |
8; 23 | 0.001 sig |
| SECONDARY ICU Stay [Unit: More Than 3 Days]. |
7.96; 8.78 | 0.243 |
| SECONDARY Procalcitonin [Unit: ng/mL] [Time Frame: 3 Days] |
8.65; 16.62 | 0.037 sig |
Summary
In this study the investigators going to evaluate the "CLI" as an early prognostic indicator for post-operative abdominal sepsis in critically ill patients.
Eligibility Criteria
Inclusion Criteria
- Age: ≥18 years old presented with Post-operative intra-abdominal sepsis due to secondary peritonitis.
- Sex: Both sexes.
- Post-Operative secondary peritonitis eg. Perforated viscus and abdominal abscess.
- Estimated length of ICU stays ≥48 hrs.
Exclusion Criteria
- Patient refusal.
- Advanced Liver diseases According New MELD score ≥ 20 )Kamath et al.,2001)
- Renal diseases (Moderate decrease in GFR 30-59 ml/min/1.73m²--Severe decrease in GFR 15-29 ml/min/1.73m²--Kidney failure less than 15 ml/min/1.73m² or on Hemodialysis).
- Pregnancy.
- Primary peritonitis.
- Tertiary peritonitis.
- Mortality within first 48hrs of ICU admission.
- Advanced malignancy ( Stage III localized malignancy with spreading lymph nodes Stage IV spreading to Other parts of the body such as to the liver, lungs and bones).
Data sourced from ClinicalTrials.gov (NCT06901544). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.