12,372 trials
HOCM, Hypertrophic Obstructive Cardiomyopathy
Primary: Composite of Decision to Proceed With Septal Reduction Therapy (SRT) and SRT Guideline Eligible at Week 16 — 10; 43 Participants — p=<0.0001
Hyperphosphatemia
Primary: Change in Serum Phosphorus (s-P) Level From Baseline to Week 4. — -0.84; -0.19 mg/dL — p=0.0004
Locally Advanced Cervical Cancer
Primary: Progression-free Survival (PFS) Based on the Investigator Assessment According to RECIST 1.1 or Histopathologic Confirmation of Local Tumour Progression — NA; NA Months…
Glaucoma, Open-Angle · Ocular Hypertension
Primary: Mean Change in Intra-ocular Pressure — -4.25; -3.80; -4.22; -4.00 mmHG
Venous Thromboembolism (VTE) · Pulmonary Embolism · Deep Vein Thrombosis (DVT)
Primary: Number of Participants With Symptomatic Recurrent Venous Thromboembolism During the Main Treatment Period Following Edoxaban or Standard of Care Treatment (Adjudicated…
Type 2 Diabetes
Primary: Change From Baseline in Percentage of Time With Continuous Glucose Monitoring (CGM) Sensor Glucose Values Between 70-180 Milligrams/Deciliter (mg/dL) (3.9-10.0…
Cytomegalovirus (CMV)
Primary: Number of Participants Who Achieved Confirmed Clearance of Plasma Cytomegalovirus (CMV) Deoxyribose Nucleic Acid (DNA) at the End of Study Week 8 — 212; 190 Participants
Clostridioides Difficile Infection
Primary: Number of Participants With Sustained Clinical Response (SCR) Defined as Clinical Response and no Recurrence of CDI Through 30 Days Post End of Treatment (EOT). — 238…
Peanut Allergy
Primary: Percentage of Subjects Who Tolerated a Single Highest Dose of at Least 600 mg in the Exit Double-Blind, Placebo-Controlled Food Challenge (DBPCFC) — 73.5; 6.3 Percentage…
Breast Cancer
Primary: 3-year Invasive Disease-free Survival (IDFS) Among Analyzed ITT Patients — 91.1; 93.2 percentage of participants — p=0.05
Anaplastic Ependymoma · Brain Ependymoma · Cellular Ependymoma
Primary: Event-free Survival (EFS) in Children Who Have Completely Resected Ependymoma or Achieved CR and Are Treated With Post-radiation Maintenance Chemotherapy or…
Severe Sudden Sensorineural Hearing Loss
Primary: Change in Pure Tone Audiometry PTA (dB) (Average of the Hearing Threshold of the 3 Contiguous Most Affected Hearing Frequencies in dB as Identified at Study Entry) From…
Urinary Tract Infections (UTI's)
Primary: UTI Incidence as Described Below, Over the 16 Week Study Period Following Randomization, in the LACTIN-V Treatment Group (Group A) as Compared to the Placebo Group…
Suicidal Ideation · Depression · Alcohol Abuse
Primary: Suicidal Ideation as Assessed by the Scale for Suicide Ideation (SSI) — 10.8; 12.3 score on a scale
Generalized Myasthenia Gravis
Primary: Percent Change From Baseline in Total IgG Levels at Day 29 (mITT Analysis Set) — -66.4; -62.2 percent — p=< 0.0001