Phase 2 N=10 Evaluation of Coffee Therapy for Improvement of Renal Oxygenation
Type1diabetes · Type1 Diabetes Mellitus · Diabetic Kidney Disease
Primary: Renal Oxygenation — 22.4; 22.5 s^-1
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=150 Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury
Hemorrhage · Shock · Wounds and Injuries
Primary: Change in HLA-DR Expression on Monocytes 72 Hours After Drug or Placebo Administration in Patient Groups (0g TXA (Placebo); 2g TXA; 4g TXA)." — 0.503; 0.509; 0.532 fold…
Phase 2 N=10 Effect of Inhaled Albuterol in Pulmonary Hypertension
Pulmonary Hypertension
Primary: Change in Mean Pulmonary Artery Pressure (MPAP) — 6.5; 4.3 mmHg
N/A N=65 Ventilator-induced Lung Injury Vortex in Patients With SARS-CoV-2
ARDS · Mechanical Ventilation Complication · Ventilator-Induced Lung Injury
Primary: Number of Participants Who Survived and Died — 1; 31; 14; 19 Participants
N/A N=211 The Randomized Controlled Trial of Inferior Vena Cava Ultrasound-guided Fluid Management in Septic Shock Resuscitation
Septic Shock
Primary: 30-day Mortality — 20; 19 Participants
Phase 2 N=56 The Safety and Efficacy of an Antibiotic Sponge in Diabetic Patients With Moderately Infected Foot Ulcers
Diabetic Foot Ulcer
Primary: Number of Participants With a Clinical Cure at Visit 3 (Day 7) — 0; 3 Participants
N/A N=200 Use of Pediatric Size Phlebotomy Tubes in Adult Critically Ill Patients to Reduce Red Blood Cell Transfusions
Anemia
Primary: Number of Participants Who Had Hemoglobin Less Than 7 g/dL or Red Blood Cell (RBC) Transfusion Order — 6; 11 Participants
Phase 3 N=211 Characterization of the Role of Histamine in Children With Asthma
Asthma · Allergic Asthma · Non-allergic Asthma
Primary: Characterize Contribution of Histamine in Children With Asthma — 11253.24; 6464.20; 3539.67 flux units on a continuous scale
N/A N=37 Clinical Calibration & Validation of a Next-Generation Blood Pressure Monitor for Patient Management
Hypertension
Primary: Systolic Pressure — 133.4 mmHg
N/A N=72 The Prone to Supine Breast MRI Trial
Breast Cancer
Primary: Number of Successful Segmentation of Supine MRI Images — 54; 61 Participants
Phase 3 N=570 Study to Evaluate the Immune Response After a Booster Dose of a Quadrivalent Meningococcal (MenACYW) Conjugate Vaccine When Administered Alone or Concomitantly With a Licensed Meningococcal Serogroup B Vaccine, in Participants Who Received Primary Quadrivalent Meningococcal Conjugate Vaccine (MCV4)
Meningococcal Immunisation (Healthy Volunteers)
Primary: Percentage of Participants With Vaccine Seroresponse Against Meningococcal Serogroups A, C, Y, and W Following Vaccination With MenACYW Conjugate Vaccine in Study MET59…
N/A N=65 Beta-lactam Pharmacokinetics in Secondary Care
Pharmacokinetics · Beta Lactam Adverse Reaction · Penicillin Allergy
Primary: Fraction of the Dosing Interval Over Which the Concentration of Unbound Drug is Greater Than the Minimum Inhibitory Concentration (fT>MIC) — 0.457; 0.429; 0.747; 0.417…
Phase 2 N=97 A Study to Investigate Intravenous Tocilizumab in Participants With Moderate to Severe COVID-19 Pneumonia
COVID-19 Pneumonia
Primary: Area Under the Curve From Day 0-28 (AUC0-d28) of Tocilizumab) — 371; 849; 837; 1330 µg/mL*day
N/A N=6,788 Early Intervention Efficacy in COPD
Pulmonary Disease, Chronic Obstructive
Primary: Time to Triple Therapy Initiation — 195.0; 89.5 Days
N/A N=101 Use of Repetitive Transcranial Magnetic Stimulation to Augment Hypnotic Analgesia
Fibromyalgia
Primary: The Change in Functional Connectivity (FC) Between the Left Dorsolateral Prefrontal Cortex (L-DLPFC) and the Dorsal Anterior Cingulate Cortex (dACC) — 61.98; 4.16…