Phase 4 N=8 Neoadjuvant Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in Cutaneous Stage L-lll Melanoma
Melanoma
Primary: Th1/Th2 Normalized Gene Expression — 1.029; 0.119; 0.074; 0.192 fold change
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=153 A Text Messaging Program for Smokers in Primary Care
Smoking Cessation
Primary: Quit Attempts — 26; 33; 29; 31 Participants — p=0.07
Phase 4 N=4,614 A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart
Acute Coronary Syndromes
Primary: The Rate of International Society on Thrombosis and Haemostasis (ISTH) Major or Clinically Relevant Non-Major (CRNM) Bleeding With Apixaban Versus Vitamin K Antagonist…
Phase 4 N=50 Platelet Inhibition With Cangrelor and Crushed Ticagrelor in STEMI
ST Segment Elevation Myocardial Infarction · Percutaneous Coronary Intervention
Primary: Platelet Reactivity Measured by VerifyNow PRU — 63; 214 P2Y12 reaction units (PRU) — p=<0.001
Phase 4 N=140 Feasibility of Vaginal Progesterone to Reduce HIV-Associated Preterm Birth
PreTerm Birth
Primary: Adequate Adherence to Study Product — 62; 63 Participants
Phase 4 N=150 Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients
Wounds and Injuries · Rib Fractures
Primary: Visual Analog Numeric Pain Score — 6.1; 5.7; 5.2; 5.1 score on a scale
Phase 4 N=106 Trial Evaluating the Efficacy and Safety of Perampanel Added to Monotherapy in Participants With Partial Onset Seizures With or Without Secondary Generalization
Epilepsy
Primary: 50 Percent (%) Responder Rate for Partial Onset Seizure With or Without Secondary Generalization — 80.0 percentage of participants
Phase 4 N=437 A Clinical Study to Evaluate the Effect of the Connected Inhaler System (CIS) on Adherence to Maintenance Therapy in Poorly Controlled Asthmatic Subjects
Asthma
Primary: Percentage of ELLIPTA Doses Taken (Daily Adherence) Between Month 4 and Month 6 as Determined by the Maintenance Sensor for Arms; ("Cohort 1: Data on Maintenance Use…
Phase 4 N=20 Effects of Dry Eye Treatments on the Ocular Surface
Keratoconjunctivitis Sicca · Dry Eye Syndrome
Primary: Changes in Corneal Fluorescein Staining — 22.18; -3.35 units on a scale — p=<0.05
Phase 4 N=66 The Efficacy and Population Pharmacokinetics of Tranexamic Acid for Craniosynostosis Surgery
Craniosynostosis
Primary: Efficacy of TXA in Childrens Having Craniosynostosis Surgery — 23.6; 21.3 mL/kg
Phase 4 N=23 Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot)
Hypogonadism · Severe Obesity
Primary: Percent Change in Muscle Strength as Assessed by Knee Extension and Knee Flexion — 12.6; 8.9; 12.8; 3.7 Percent change in muscle strength
Phase 4 N=70 Pilot - Peri-operative Beta Blockade
Adrenergic Beta-Receptor Blockader · Troponin Levels · Cardiomyopathy, Post-surgical
Primary: Difference in hscTnI Values — 3.4; 2.8 ng/L
Phase 4 N=31 Evaluation of the Effect of Intravitreal Injections of Anti-VEGF on Macular Perfusion in Diabetic Patients Using OCTA
Diabetic Macular Edema · Ischemic Maculopathy
Primary: FAZ Area Change — 0.03 mm^2
Phase 4 N=112 Smoking Cessation Treatment for Methadone Maintenance Patients
Smoking Cessation · Substance-Related Disorders
Primary: Biochemically Verified Abstinence Verified With Expired Carbon Monoxide (CO) < 8 p.p.m. — 6; 0 participants — p=0.03
Phase 4 N=50 Drug Interactions Between Morphine and Orally or IV Administered Acetaminophen
Pain
Primary: Area Under the Plasma Concentration-time Curve Over 6 Hours (AUC6) for Acetaminophen — 31.00; 28.51; 25.31; 52.38 hour*microgram per milliliter (h*mcg/mL)