Phase 4 N=5 Prednisolone Pharmacokinetics in Severe Asthma
Asthma
Primary: Serum Prednisolone Levels Over 24 Hours — 800; 700; NA nmol/l
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=19 The Safety, Pharmacokinetic Profile and Efficacy of Raltegravir in HIV-infected Patients at Least 60 Years of Age
HIV
Primary: Drug Levels in Blood — 1732 ng/ml
Phase 4 N=25 Effectiveness of Flutamide in Treating Women With Premenstrual Dysphoric Disorder
Premenstrual Syndrome
Primary: Change in Premenstrual Symptoms as Measured by the Premenstrual Tension Scale (PMTS) — -6.9; -5.5; -5.5; -8.3 score on a scale — p== 0.57
Phase 4 N=31 Genetics and HIV-1 Protease Inhibitors
HIV
Primary: Day 7 Atazanavir Oral Clearance — .25; .18 L/h/kg
Phase 4 N=10 Impact of Everolimus on HIV Persistence Post Kidney or Liver Transplant
HIV · Kidney Transplant · Liver Transplant
Primary: Cell-associated HIV DNA — 35; 43; 81; 16 nucleic acid copies per million cells
Phase 4 N=21 The Clinical Effect of Monodisperse Fluticasone Propionate in Asthma
Asthma
Primary: AMP Challenge Test PC20 — 79.21; 79.74; 62.69; 92.1 mg/ml
Phase 4 N=8 A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia
Anesthesia
Primary: Waking Time - Time Between Terminating Anesthesia and Subject Opening Eyes.
Phase 4 N=67 Adapalene 0.3% - Benzoyl Peroxide 2.5% Gel and Risk of Formation of Atrophic Acne Scars
Acne Vulgaris · Atrophic Acne Scars
Primary: Part 1: Total Atrophic Acne Scar Count Per Half-face — 9.5; 13.3 atrophic acne scars — p=<0.0001
Phase 4 N=58 Tobacco and Socioeconomic Disadvantage
Tobacco Smoking
Primary: Self-reported Serious Quit Attempt Measured Via the 'Quitting Preparation and Actions Questionnaire' — 5; 10; 6 Participants — p=<0.05
Phase 4 N=200 Ciprofloxacin for Prevention of BK Infection
BK Virus Infection
Primary: Number of Patients Developing BK Infection at 6 Months Post-transplant — 25; 5 Participants
Phase 4 N=33 Neuroimaging During Pure Oxygen Breathing
Hyperoxia · Hypoxia, Brain · Neurobehavioral Manifestations
Primary: Cerebral Blood Flow — 48.54; 36.17 ml/min/100g tissue — p=<0.05
Phase 4 N=64 Perimenopausal Effects of Estradiol on Reward Responsiveness
Perimenopausal Depression
Primary: Caudate Signal Intensity in Response to Reward During the MID fMRI Task at Pre-treatment — .027; .043 percent signal change — p=.620
Phase 4 N=117 Efficacy and Safety of Elbasvir (MK-8742) + Grazoprevir (MK-5172) in Treatment-Naïve/Treatment-Experienced (TN/TE) French Participants With Hepatitis C Virus (HCV) Genotype 4 (GT4) Infection (MK-5172-096)
Hepatitis C Virus (HCV) Infection
Primary: Percentage of Participants Achieving Sustained Virologic Response 12 Weeks After End of Treatment (SVR12) — 94.3; 95.3 Percentage of Participants
Phase 4 N=36 Spinal Versus General Anesthesia With Popliteal and Adductor Canal Blocks for Ambulatory Foot and Ankle Surgery.
Nerve Block · General Anesthesia · Spinal Anesthesia
Primary: Time Until Patient is Ready for Discharge From Post-Anesthesia Care Unit (PACU) to Home. — 81; 43.5 Minutes
Phase 4 N=166 Immunologic Response to Influenza Vaccination in Children and Adolescents
Influenza, Human · Immune Response
Primary: Determining Seroconversion Response - Change in HI Titers From Pre- to Post Vaccination — 20; 14; 9; 11 Participants — p=0.28