12,372 trials
Hereditary Angioedema
Primary: Number of Participants With Adverse Events Including Serious Adverse Events (SAEs) and Adverse Events of Special Interest (AESIs) — 0; 0; 0; 0 Participants
Sphingomyelin Lipidosis
Primary: Percent Predicted (% Predicted) Hemoglobin (Hb) and Altitude-Adjusted Diffusing Capacity of the Lung for Carbon Monoxide (DLco) at Baseline — 48.45; 49.44 % Predicted DLco
Pyruvate Kinase Deficiency · Anemia, Hemolytic
Primary: Percentage of Participants Achieving a Hemoglobin (Hb) Response (HR) — 0; 40.0 percentage of participants — p=<0.0001
Short Bowel Syndrome
Primary: Number of Participants With Treatment-emergent Adverse Events (TEAEs) — 7; 2 Participants
Depressive Disorder, Treatment-Resistant
Primary: Change From Baseline in Montgomery Asberg Depression Rating Scale (MADRS) Total Score to the End of Double-blind Treatment Phase (Day 28) — -10.1; -8.1 Units on a Scale…
Post-Traumatic Stress Disorder
Primary: PTSD Symptoms — 10.02; 10.87; 15.12; 10.78 units on a scale
Chronic Lymphocytic Leukemia
Primary: Overall Response Rate (ORR) — 84.4; 69.4 percentage of participants — p=0.0463
Arthritis Knee · Pain, Postoperative · Opioid Use
Primary: Hospital Length of Stay — 36.3; 49.7 Hours — p=<0.05
Non-small Cell Lung Cancer
Primary: Overall Survival of Standard Radiation (CFRT) Versus Accelerated, Hypofractionated, Image-guided Conformal Radiotherapy (IGRT) in Treatment of Stage II-III NSCLC in…
Episodic Migraine
Primary: Percentage of Participants With at Least 1 Treatment-Emergent Adverse Event and Treatment-Emergent Serious Adverse Event (TEAEs/TESAEs) — 62.5; 3.4 percentage of…
Bile Acid Synthesis Defect · Inborn Error of Bile Acid Metabolism · Inborn Error of Bile Acid Conjugation
Primary: Conjugated Cholic Acid (GCA) for the Treatment of Inborn Errors in Bile Acid Synthesis Involving Side-chain Conjugation. — 5 Participants
Multiple Myeloma
Primary: Comparison of Progression Free Survival Between Treatment Arms (Daratumumab /Pomalidomide /Dexamethasone vs Pomalidomide / Dexamethasone) — 24.41; 17.58; 12.42; 6.93…
Rotator Cuff Tear · Postoperative Pain
Primary: Postoperative Visual Analog Scale Scores — 30; 20 score/units on a scale
Pneumococcal Infections
Primary: Percentage of Participants With a Solicited Injection-site Adverse Event — 43.9; 36.0; 25.3; 25.6 Percentage of participants — p== 0.003
Metastatic Castration-resistant Prostate Cancer · Metastatic Breast Cancer
Primary: Number of Participants With Serious Adverse Events (SAEs) — 16 Participants